Zhang Gene-Tissue Expression and Enrichment Report

Run Configuration

Report Thresholds

Table of Contents

• Clustering k = 5
  • Resolution Visualizations
  • Cluster 1
  • Cluster 2
  • Cluster 3
  • Cluster 4
  • Cluster 5
• Clustering k = 11
  • Resolution Visualizations
  • Cluster 1
  • Cluster 2
  • Cluster 3
  • Cluster 4
  • Cluster 5
  • Cluster 6
  • Cluster 7
  • Cluster 8
  • Cluster 9
  • Cluster 10
  • Cluster 11
• Clustering k = 21
  • Resolution Visualizations
  • Cluster 1
  • Cluster 2
  • Cluster 3
  • Cluster 4
  • Cluster 5
  • Cluster 6
  • Cluster 7
  • Cluster 8
  • Cluster 9
  • Cluster 10
  • Cluster 11
  • Cluster 12
  • Cluster 13
  • Cluster 14
  • Cluster 15
  • Cluster 16
  • Cluster 17
  • Cluster 18
  • Cluster 19
  • Cluster 20
  • Cluster 21

Resolution Visualizations (k=5)

Cluster 1 (k=5)

This cluster contains 46 genes.
Average Silhouette Score: 0.118.
Highest expression is observed in: Whole Blood, Spleen, Cells - EBV-transformed lymphocytes, Lung, Uterus.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Intracellular (GOCC:0005622) (FDR: 1.70e-04); Protein-containing complex (GOCC:0032991) (FDR: 1.70e-04); Nucleoplasm (GOCC:0005654) (FDR: 4.40e-04); Cytosol (GOCC:0005829) (FDR: 4.40e-04); Intracellular organelle lumen (GOCC:0070013) (FDR: 4.40e-04) ... *(Total significant: 13. See string_terms.csv for full list.)*
- Process: Coenzyme A biosynthetic process (GO:0015937) (FDR: 5.40e-04); Purine ribonucleotide biosynthetic process (GO:0009152) (FDR: 0.001); Nucleotide biosynthetic process (GO:0009165) (FDR: 0.001); Nucleobase-containing small molecule metabolic process (GO:0055086) (FDR: 0.002); Nucleotide metabolic process (GO:0009117) (FDR: 0.003) ... *(Total significant: 26. See string_terms.csv for full list.)*
- Component: Intracellular organelle lumen (GO:0070013) (FDR: 1.30e-04); Catalytic complex (GO:1902494) (FDR: 6.50e-04); Cytosol (GO:0005829) (FDR: 0.001); Nucleoplasm (GO:0005654) (FDR: 0.001); Protein-containing complex (GO:0032991) (FDR: 0.004) ... *(Total significant: 7. See string_terms.csv for full list.)*
- TISSUES: Gland (BTO:0000522) (FDR: 1.02e-05); Endocrine gland (BTO:0001488) (FDR: 1.34e-05); Respiratory system (BTO:0000203) (FDR: 1.10e-04); Whole body (BTO:0001489) (FDR: 1.10e-04); Lung (BTO:0000763) (FDR: 1.80e-04) ... *(Total significant: 20. See string_terms.csv for full list.)*
- DISEASES: Pantothenate kinase-associated neurodegeneration (DOID:3981) (FDR: 0.004) *(Total significant: 1)*
- Keyword: Coenzyme A biosynthesis (KW-0173) (FDR: 3.60e-06); Acetylation (KW-0007) (FDR: 0.002); Host-virus interaction (KW-0945) (FDR: 0.008); Kinase (KW-0418) (FDR: 0.016); Phosphoprotein (KW-0597) (FDR: 0.016) ... *(Total significant: 9. See string_terms.csv for full list.)*
- KEGG: Pantothenate and CoA biosynthesis (hsa00770) (FDR: 8.89e-05); Human papillomavirus infection (hsa05165) (FDR: 1.10e-04); Human T-cell leukemia virus 1 infection (hsa05166) (FDR: 1.10e-04); Thyroid hormone signaling pathway (hsa04919) (FDR: 8.80e-04); Purine metabolism (hsa00230) (FDR: 9.10e-04) ... *(Total significant: 59. See string_terms.csv for full list.)*
- PMID: (2021) Turnover rate of coenzyme A in mouse brain and liver. (PMID:34019583) (FDR: 0.028); (2022) Targeting CDK4 and CDK6 in cancer. (PMID:35304604) (FDR: 0.029); (2021) Tumor-Associated Microbiota in Proximal and Distal Colorectal Cancer and Their Relationships With Clinical Outcomes. (PMID:34650531) (FDR: 0.029); (2019) Mutation Profiles in Glioblastoma 3D Oncospheres Modulate Drug Efficacy. (PMID:30289729) (FDR: 0.029); (2005) metaSHARK: software for automated metabolic network prediction from DNA sequence and its application to the genomes of Plasmodium falciparum and Eimeria tenella. (PMID:15745999) (FDR: 0.029) *(Total significant: 5)*
- RCTM: Coenzyme A biosynthesis (HSA-196783) (FDR: 2.87e-05); APC/C-mediated degradation of cell cycle proteins (HSA-174143) (FDR: 8.52e-05); Downstream signaling events of B Cell Receptor (BCR) (HSA-1168372) (FDR: 3.00e-04); Cdc20:Phospho-APC/C mediated degradation of Cyclin A (HSA-174184) (FDR: 3.00e-04); Regulation of APC/C activators between G1/S and early anaphase (HSA-176408) (FDR: 3.00e-04) ... *(Total significant: 132. See string_terms.csv for full list.)*
- WikiPathways: Proteasome degradation (WP183) (FDR: 0.013); Alzheimers disease and miRNA effects (WP2059) (FDR: 0.013); PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (WP3844) (FDR: 0.013); Head and neck squamous cell carcinoma (WP4674) (FDR: 0.013); Alzheimers disease (WP5124) (FDR: 0.013) ... *(Total significant: 11. See string_terms.csv for full list.)*
- HPO: Ascites (HP:0001541) (FDR: 0.027); Hemimegalencephaly (HP:0007206) (FDR: 0.027); Renal neoplasm (HP:0009726) (FDR: 0.027); Renal cell carcinoma (HP:0005584) (FDR: 0.036); Adenoma sebaceum (HP:0009720) (FDR: 0.036) ... *(Total significant: 12. See string_terms.csv for full list.)*
- NetworkNeighborAL: Coenzyme A biosynthesis (CL:11025) (FDR: 2.45e-05); Spliceosomal snRNP complex, and mRNA cis splicing, via spliceosome (CL:2036) (FDR: 0.030) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Coenzyme A Biosynthetic Process (GO:0015937) (Adj. P: 9.88e-07, Combined Score: 7449.63); Nucleoside Phosphate Biosynthetic Process (GO:1901293) (Adj. P: 1.81e-09, Combined Score: 6120.91); Coenzyme A Metabolic Process (GO:0015936) (Adj. P: 5.19e-06, Combined Score: 3331.82); Purine-Containing Compound Biosynthetic Process (GO:0072522) (Adj. P: 4.06e-05, Combined Score: 1442.43); Anoikis (GO:0043276) (Adj. P: 0.008, Combined Score: 1337.16) ... *(Total significant: 17. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Adenylate Kinase Activity (GO:0004017) (Adj. P: 0.008, Combined Score: 2146.78); Nucleoside Monophosphate Kinase Activity (GO:0050145) (Adj. P: 0.025, Combined Score: 405.82); Nucleobase-Containing Compound Kinase Activity (GO:0019205) (Adj. P: 0.025, Combined Score: 349.94); Phosphotransferase Activity, Phosphate Group as Acceptor (GO:0016776) (Adj. P: 0.029, Combined Score: 242.44); Pentosyltransferase Activity (GO:0016763) (Adj. P: 0.040, Combined Score: 160.01) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- Reactome_2022: Coenzyme A Biosynthesis R-HSA-196783 (Adj. P: 8.48e-07, Combined Score: 9590.91); Vitamin B5 (Pantothenate) Metabolism R-HSA-199220 (Adj. P: 9.46e-06, Combined Score: 2436.76); Signaling By FLT3 ITD And TKD Mutants R-HSA-9703648 (Adj. P: 1.15e-04, Combined Score: 1413.33); Signaling By FGFR4 In Disease R-HSA-5655291 (Adj. P: 0.001, Combined Score: 949.33); Signaling By PDGFRA Extracellular Domain Mutants R-HSA-9673770 (Adj. P: 0.002, Combined Score: 823.74) ... *(Total significant: 273. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Hamartoma of the eye (HP:0010568) (Adj. P: 0.021, Combined Score: 645.35); Hamartoma (HP:0010566) (Adj. P: 0.006, Combined Score: 541.65); Visceral angiomatosis (HP:0100761) (Adj. P: 0.021, Combined Score: 479.38); Renal cell carcinoma (HP:0005584) (Adj. P: 0.006, Combined Score: 471.13); Adenoma sebaceum (HP:0009720) (Adj. P: 0.021, Combined Score: 439.93) ... *(Total significant: 54. See enrichr_terms.csv for full list.)*
- OMIM_Disease: colorectal cancer (Adj. P: 0.046, Combined Score: 132.65) *(Total significant: 1)*

Top Genes (by silhouette):

Cluster 2 (k=5)

This cluster contains 22 genes.
Average Silhouette Score: 0.140.
Highest expression is observed in: Cells - Cultured fibroblasts, Artery - Aorta, Artery - Tibial, Fallopian Tube, Uterus.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Proteasome complex (GOCC:0000502) (FDR: 0.002); Methyltransferase complex (GOCC:0034708) (FDR: 0.006); Catalytic complex (GOCC:1902494) (FDR: 0.023); Proteasome regulatory particle, base subcomplex (GOCC:0008540) (FDR: 0.025); Proteasome core complex, beta-subunit complex (GOCC:0019774) (FDR: 0.030) *(Total significant: 5)*
- Component: Proteasome complex (GO:0000502) (FDR: 0.002); Proteasome regulatory particle, base subcomplex (GO:0008540) (FDR: 0.033); Proteasome core complex, beta-subunit complex (GO:0019774) (FDR: 0.038) *(Total significant: 3)*
- Keyword: Proteasome (KW-0647) (FDR: 2.80e-04); Nucleotide metabolism (KW-0546) (FDR: 0.002) *(Total significant: 2)*
- KEGG: Proteasome (hsa03050) (FDR: 6.74e-05); Prion disease (hsa05020) (FDR: 0.002); Huntington disease (hsa05016) (FDR: 0.002); Spinocerebellar ataxia (hsa05017) (FDR: 0.002); Pyrimidine metabolism (hsa00240) (FDR: 0.002) ... *(Total significant: 9. See string_terms.csv for full list.)*
- RCTM: Regulation of RAS by GAPs (HSA-5658442) (FDR: 3.23e-05); HIV Infection (HSA-162906) (FDR: 2.00e-04); Activation of NF-kappaB in B cells (HSA-1169091) (FDR: 2.50e-04); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (HSA-1234176) (FDR: 2.50e-04); ER-Phagosome pathway (HSA-1236974) (FDR: 2.50e-04) ... *(Total significant: 70. See string_terms.csv for full list.)*
- WikiPathways: Proteasome degradation (WP183) (FDR: 6.20e-04) *(Total significant: 1)*
- NetworkNeighborAL: Mixed, incl. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, and Ubiquitin conjugating enzyme activity (CL:3694) (FDR: 8.40e-04); Proteasome (CL:3706) (FDR: 8.40e-04); Proteasome, subunit alpha/beta, and Proteasome regulatory particle, base subcomplex (CL:3709) (FDR: 8.40e-04); Proteasome regulatory particle, base subcomplex, and Proteasome alpha-type subunit (CL:3710) (FDR: 0.024); Nucleoside diphosphate kinase, active site, and dGDP metabolic process (CL:10686) (FDR: 0.032) ... *(Total significant: 6. See string_terms.csv for full list.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulatory ncRNA-mediated Gene Silencing (GO:0031047) (Adj. P: 0.035, Combined Score: 409.88); Positive Regulation of Proteolysis Involved in Protein Catabolic Process (GO:1903052) (Adj. P: 0.035, Combined Score: 369.28); Positive Regulation of Protein Catabolic Process (GO:0045732) (Adj. P: 0.017, Combined Score: 283.99); Regulation of Stem Cell Population Maintenance (GO:2000036) (Adj. P: 0.042, Combined Score: 234.95); Regulation of Proteasomal Protein Catabolic Process (GO:0061136) (Adj. P: 0.042, Combined Score: 234.95) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Nucleoside Diphosphate Kinase Activity (GO:0004550) (Adj. P: 0.006, Combined Score: 1525.49); lncRNA Binding (GO:0106222) (Adj. P: 0.027, Combined Score: 1237.70); DNA-methyltransferase Activity (GO:0009008) (Adj. P: 0.027, Combined Score: 1237.70); Potassium Channel Inhibitor Activity (GO:0019870) (Adj. P: 0.027, Combined Score: 955.53); RNA Polymerase II C-terminal Domain Binding (GO:0099122) (Adj. P: 0.027, Combined Score: 955.53) ... *(Total significant: 24. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: RNA N6-methyladenosine Methyltransferase Complex (GO:0036396) (Adj. P: 0.042, Combined Score: 643.51); MLL1 Complex (GO:0071339) (Adj. P: 0.006, Combined Score: 542.55); MLL1/2 Complex (GO:0044665) (Adj. P: 0.006, Combined Score: 519.27); Cytoplasmic Vesicle Lumen (GO:0060205) (Adj. P: 0.042, Combined Score: 85.07); Ficolin-1-Rich Granule Lumen (GO:1904813) (Adj. P: 0.042, Combined Score: 79.24) *(Total significant: 5)*
- Reactome_2022: Regulation Of RAS By GAPs R-HSA-5658442 (Adj. P: 1.88e-06, Combined Score: 1822.56); Cross-presentation Of Soluble Exogenous Antigens (Endosomes) R-HSA-1236978 (Adj. P: 3.84e-06, Combined Score: 1549.53); Regulation Of Activated PAK-2p34 By Proteasome Mediated Degradation R-HSA-211733 (Adj. P: 3.84e-06, Combined Score: 1506.71); Regulation Of Ornithine Decarboxylase (ODC) R-HSA-350562 (Adj. P: 3.84e-06, Combined Score: 1465.92); GSK3B And BTRC:CUL1-mediated-degradation Of NFE2L2 R-HSA-9762114 (Adj. P: 3.84e-06, Combined Score: 1427.03) ... *(Total significant: 184. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: DNA Repair (Adj. P: 0.003, Combined Score: 158.98) *(Total significant: 1)*

Top Genes (by silhouette):

Cluster 3 (k=5)

This cluster contains 9 genes.
Average Silhouette Score: -0.029.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Adipose - Subcutaneous, Cells - Cultured fibroblasts, Spleen, Whole Blood.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Process: Cellular response to organonitrogen compound (GO:0071417) (FDR: 0.039) *(Total significant: 1)*
- Keyword: Nucleotide metabolism (KW-0546) (FDR: 0.047) *(Total significant: 1)*
- KEGG: Purine metabolism (hsa00230) (FDR: 0.008); JAK-STAT signaling pathway (hsa04630) (FDR: 0.008); Renal cell carcinoma (hsa05211) (FDR: 0.045) *(Total significant: 3)*
- RCTM: MET activates RAP1 and RAC1 (HSA-8875555) (FDR: 0.033); Erythropoietin activates RAS (HSA-9027284) (FDR: 0.033); Regulation of signaling by CBL (HSA-912631) (FDR: 0.039); Downstream signal transduction (HSA-186763) (FDR: 0.039); Signalling to ERKs (HSA-187687) (FDR: 0.044) *(Total significant: 5)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Natural Killer Cell Mediated Cytotoxicity (GO:0042269) (Adj. P: 1.08e-04, Combined Score: 4421.54); Regulation of Natural Killer Cell Activation (GO:0032814) (Adj. P: 0.002, Combined Score: 4381.12); Regulation of Relaxation of Cardiac Muscle (GO:1901897) (Adj. P: 0.024, Combined Score: 3808.55); + Reg of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target (GO:0002860) (Adj. P: 0.024, Combined Score: 3808.55); Positive Regulation of Natural Killer Cell Mediated Immune Response to Tumor Cell (GO:0002857) (Adj. P: 0.024, Combined Score: 3808.55) ... *(Total significant: 181. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Neurotrophin TRK Receptor Binding (GO:0005167) (Adj. P: 0.026, Combined Score: 3808.55); Neurotrophin TRKA Receptor Binding (GO:0005168) (Adj. P: 0.026, Combined Score: 3808.55); cAMP Response Element Binding (GO:0035497) (Adj. P: 0.026, Combined Score: 1720.62); Peptide Hormone Receptor Binding (GO:0051428) (Adj. P: 0.026, Combined Score: 1070.48); DNA Replication Origin Binding (GO:0003688) (Adj. P: 0.026, Combined Score: 1070.48) ... *(Total significant: 30. See enrichr_terms.csv for full list.)*
- Reactome_2022: MET Activates RAP1 And RAC1 R-HSA-8875555 (Adj. P: 0.001, Combined Score: 7310.93); Erythropoietin Activates RAS R-HSA-9027284 (Adj. P: 0.001, Combined Score: 5800.00); MET Activates PTPN11 R-HSA-8865999 (Adj. P: 0.025, Combined Score: 3808.55); Regulation Of Signaling By CBL R-HSA-912631 (Adj. P: 0.002, Combined Score: 3746.60); Activated NTRK2 Signals Thru PI3K R-HSA-9028335 (Adj. P: 0.025, Combined Score: 2955.69) ... *(Total significant: 157. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: DNA Repair (Adj. P: 0.024, Combined Score: 239.17); Allograft Rejection (Adj. P: 0.024, Combined Score: 162.17) *(Total significant: 2)*
- Human_Phenotype_Ontology: Birth length less than 3rd percentile (HP:0003561) (Adj. P: 0.031, Combined Score: 2008.48); Hypoplasia of the capital femoral epiphysis (HP:0003090) (Adj. P: 0.031, Combined Score: 1720.62); Abnormal pupillary function (HP:0007686) (Adj. P: 0.031, Combined Score: 1720.62); Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) (Adj. P: 0.031, Combined Score: 1326.33); Irregular epiphyses (HP:0010582) (Adj. P: 0.031, Combined Score: 1326.33) ... *(Total significant: 44. See enrichr_terms.csv for full list.)*
- OMIM_Disease: hypogonadism (Adj. P: 0.013, Combined Score: 892.01); obesity (Adj. P: 0.014, Combined Score: 355.83) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 4 (k=5)

This cluster contains 15 genes.
Average Silhouette Score: 0.014.
Highest expression is observed in: Liver, Esophagus - Mucosa, Skin - Not Sun Exposed (Suprapubic), Skin - Sun Exposed (Lower leg), Vagina.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Cytosol (GOCC:0005829) (FDR: 0.026) *(Total significant: 1)*
- Component: Apical part of cell (GO:0045177) (FDR: 0.027) *(Total significant: 1)*
- KEGG: Metabolic pathways (hsa01100) (FDR: 0.001); Collecting duct acid secretion (hsa04966) (FDR: 0.029) *(Total significant: 2)*
- PMID: (2010) A host defense mechanism involving CFTR-mediated bicarbonate secretion in bacterial prostatitis. (PMID:21151921) (FDR: 0.002) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Respiratory Burst Involved in Inflammatory Response (GO:0060264) (Adj. P: 0.045, Combined Score: 1993.61); Regulation of Monoatomic Anion Transport (GO:0044070) (Adj. P: 0.045, Combined Score: 1993.61); Negative Regulation of Acute Inflammatory Response (GO:0002674) (Adj. P: 0.045, Combined Score: 1993.61); Nucleoside Diphosphate Metabolic Process (GO:0009132) (Adj. P: 0.045, Combined Score: 1542.87); L-methionine Salvage (GO:0071267) (Adj. P: 0.045, Combined Score: 1542.87) ... *(Total significant: 101. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Arylesterase Activity (GO:0004064) (Adj. P: 0.026, Combined Score: 1993.61); DNA-methyltransferase Activity (GO:0009008) (Adj. P: 0.026, Combined Score: 1993.61); P-type Potassium Transmembrane Transporter Activity (GO:0008556) (Adj. P: 0.026, Combined Score: 1542.87); Serine-Type Exopeptidase Activity (GO:0070008) (Adj. P: 0.026, Combined Score: 1542.87); G Protein-Coupled Glutamate Receptor Binding (GO:0035256) (Adj. P: 0.026, Combined Score: 1249.08) ... *(Total significant: 17. See enrichr_terms.csv for full list.)*
- OMIM_Disease: anomalies (Adj. P: 0.015, Combined Score: 551.00); epidermolysis bullosa (Adj. P: 0.015, Combined Score: 551.00); immunodeficiency (Adj. P: 0.021, Combined Score: 204.47) *(Total significant: 3)*

Top Genes (by silhouette):

Cluster 5 (k=5)

This cluster contains 22 genes.
Average Silhouette Score: 0.189.
Highest expression is observed in: Brain - Frontal Cortex (BA9), Brain - Cortex, Brain - Anterior cingulate cortex (BA24), Brain - Cerebellar Hemisphere, Brain - Nucleus accumbens (basal ganglia).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Neuron to neuron synapse (GOCC:0098984) (FDR: 5.76e-08); Postsynaptic specialization (GOCC:0099572) (FDR: 5.76e-08); Postsynaptic density (GOCC:0014069) (FDR: 1.05e-06); Synapse (GOCC:0045202) (FDR: 1.05e-06); Cell junction (GOCC:0030054) (FDR: 2.33e-05) ... *(Total significant: 11. See string_terms.csv for full list.)*
- Process: Regulation of nervous system process (GO:0031644) (FDR: 3.41e-06); Modulation of chemical synaptic transmission (GO:0050804) (FDR: 4.21e-06); Chemical synaptic transmission (GO:0007268) (FDR: 3.61e-05); Regulation of neurotransmitter receptor activity (GO:0099601) (FDR: 3.61e-05); Regulation of system process (GO:0044057) (FDR: 1.90e-04) ... *(Total significant: 20. See string_terms.csv for full list.)*
- Component: Neuron to neuron synapse (GO:0098984) (FDR: 1.45e-07); Postsynaptic specialization (GO:0099572) (FDR: 1.45e-07); Postsynapse (GO:0098794) (FDR: 3.27e-07); Postsynaptic density (GO:0014069) (FDR: 7.90e-07); Synapse (GO:0045202) (FDR: 1.92e-05) ... *(Total significant: 24. See string_terms.csv for full list.)*
- Keyword: Synapse (KW-0770) (FDR: 1.55e-05); Cell junction (KW-0965) (FDR: 3.57e-05); Spinocerebellar ataxia (KW-0950) (FDR: 0.003); One-carbon metabolism (KW-0554) (FDR: 0.041) *(Total significant: 4)*
- SMART: S-adenosyl-L-homocysteine hydrolase, NAD binding domain (SM00997) (FDR: 0.010) *(Total significant: 1)*
- InterPro: SAPAP family (IPR005026) (FDR: 4.80e-04); Adenosylhomocysteinase-like (IPR000043) (FDR: 0.043); Neuroligin (IPR000460) (FDR: 0.043); S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878) (FDR: 0.043); S-adenosyl-L-homocysteine hydrolase, conserved site (IPR020082) (FDR: 0.043) ... *(Total significant: 6. See string_terms.csv for full list.)*
- Pfam: Guanylate-kinase-associated protein (GKAP) protein (PF03359) (FDR: 1.60e-04) *(Total significant: 1)*
- PMID: (2017) Proteomic Analysis of Postsynaptic Protein Complexes Underlying Neuronal Plasticity. (PMID:28211672) (FDR: 5.39e-09); (2021) Shankopathies in the Developing Brain in Autism Spectrum Disorders. (PMID:35002604) (FDR: 3.62e-06); (2017) PKCalpha-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory. (PMID:28687800) (FDR: 3.62e-06); (2022) SAPAP Scaffold Proteins: From Synaptic Function to Neuropsychiatric Disorders. (PMID:36497075) (FDR: 1.40e-05); (2013) CaMKII regulates diacylglycerol lipase-alpha and striatal endocannabinoid signaling. (PMID:23502535) (FDR: 1.67e-05) ... *(Total significant: 91. See string_terms.csv for full list.)*
- RCTM: Neurexins and neuroligins (HSA-6794361) (FDR: 9.03e-10); Neuronal System (HSA-112316) (FDR: 8.18e-09) *(Total significant: 2)*
- WikiPathways: Disruption of postsynaptic signaling by CNV (WP4875) (FDR: 2.28e-09); Fragile X syndrome (WP4549) (FDR: 0.004); GPCRs, class C metabotropic glutamate, pheromone (WP501) (FDR: 0.042) *(Total significant: 3)*
- NetworkNeighborAL: Neurexins and neuroligins (CL:22982) (FDR: 2.78e-11); Neurexins and neuroligins (CL:22984) (FDR: 7.71e-08); Vocalization behavior, and Homer family (CL:22986) (FDR: 8.90e-04); Adenosylhomocysteinase-like, and Cystathioninuria (CL:9005) (FDR: 0.014); Mixed, incl. Folic acid-containing compound metabolic process, and Cysteine and methionine catabolism (CL:8941) (FDR: 0.023) *(Total significant: 5)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Postsynaptic Density Protein 95 Clustering (GO:0097119) (Adj. P: 3.98e-04, Combined Score: 7571.08); Postsynaptic Membrane Assembly (GO:0097104) (Adj. P: 3.98e-04, Combined Score: 7571.08); Postsynapse Assembly (GO:0099068) (Adj. P: 6.97e-04, Combined Score: 4246.35); Neuron Cell-Cell Adhesion (GO:0007158) (Adj. P: 4.32e-05, Combined Score: 4210.21); Positive Regulation of Synaptic Transmission, GABAergic (GO:0032230) (Adj. P: 7.16e-04, Combined Score: 3442.91) ... *(Total significant: 87. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Neurexin Family Protein Binding (GO:0042043) (Adj. P: 0.003, Combined Score: 2463.82) *(Total significant: 1)*
- GO_Cellular_Component_2025: G Protein-Coupled Receptor Dimeric Complex (GO:0038037) (Adj. P: 3.63e-04, Combined Score: 5475.89); PAR Polarity Complex (GO:0120157) (Adj. P: 0.023, Combined Score: 1237.70); Neuronal Dense Core Vesicle (GO:0098992) (Adj. P: 0.023, Combined Score: 1237.70); Symmetric Synapse (GO:0032280) (Adj. P: 0.023, Combined Score: 1237.70); GABA-ergic Synapse (GO:0098982) (Adj. P: 0.003, Combined Score: 774.71) ... *(Total significant: 18. See enrichr_terms.csv for full list.)*
- Reactome_2022: Neurexins And Neuroligins R-HSA-6794361 (Adj. P: 7.03e-09, Combined Score: 3553.04); Protein-protein Interactions At Synapses R-HSA-6794362 (Adj. P: 5.14e-08, Combined Score: 1962.31); VEGFR2 Mediated Cell Proliferation R-HSA-5218921 (Adj. P: 0.008, Combined Score: 1079.40); Neuronal System R-HSA-112316 (Adj. P: 3.60e-07, Combined Score: 569.32); GPVI-mediated Activation Cascade R-HSA-114604 (Adj. P: 0.022, Combined Score: 497.69) ... *(Total significant: 11. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Failure to thrive in infancy (HP:0001531) (Adj. P: 0.005, Combined Score: 2463.82); Sensorimotor neuropathy (HP:0007141) (Adj. P: 0.005, Combined Score: 1692.12); Dysdiadochokinesis (HP:0002075) (Adj. P: 0.007, Combined Score: 1002.87); Dysmetria (HP:0001310) (Adj. P: 0.003, Combined Score: 828.07); Neuroblastic tumors (HP:0004376) (Adj. P: 0.007, Combined Score: 774.71) ... *(Total significant: 20. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Resolution Visualizations (k=11)

Cluster 1 (k=11)

This cluster contains 29 genes.
Average Silhouette Score: 0.166.
Highest expression is observed in: Cells - Cultured fibroblasts, Cells - EBV-transformed lymphocytes, Ovary, Uterus, Cervix - Endocervix.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Nucleus (GOCC:0005634) (FDR: 0.001); Protein-containing complex (GOCC:0032991) (FDR: 0.001); Catalytic complex (GOCC:1902494) (FDR: 0.002); Nucleoplasm (GOCC:0005654) (FDR: 0.002); Intracellular organelle lumen (GOCC:0070013) (FDR: 0.009) ... *(Total significant: 13. See string_terms.csv for full list.)*
- Component: Protein-containing complex (GO:0032991) (FDR: 2.50e-04); Catalytic complex (GO:1902494) (FDR: 8.00e-04); Nucleoplasm (GO:0005654) (FDR: 9.80e-04); Intracellular organelle lumen (GO:0070013) (FDR: 9.80e-04); Nucleus (GO:0005634) (FDR: 0.003) ... *(Total significant: 9. See string_terms.csv for full list.)*
- TISSUES: Respiratory system (BTO:0000203) (FDR: 0.028); Gland (BTO:0000522) (FDR: 0.028); Leukemia cell (BTO:0001271) (FDR: 0.028); Whole plant (BTO:0001461) (FDR: 0.028); Endocrine gland (BTO:0001488) (FDR: 0.028) ... *(Total significant: 8. See string_terms.csv for full list.)*
- Keyword: Acetylation (KW-0007) (FDR: 0.003); Ubl conjugation (KW-0832) (FDR: 0.004); Isopeptide bond (KW-1017) (FDR: 0.004); Coenzyme A biosynthesis (KW-0173) (FDR: 0.009); Spliceosome (KW-0747) (FDR: 0.009) ... *(Total significant: 7. See string_terms.csv for full list.)*
- KEGG: Human T-cell leukemia virus 1 infection (hsa05166) (FDR: 2.10e-04); Autophagy - animal (hsa04140) (FDR: 0.007); Pantothenate and CoA biosynthesis (hsa00770) (FDR: 0.008); EGFR tyrosine kinase inhibitor resistance (hsa01521) (FDR: 0.008); mTOR signaling pathway (hsa04150) (FDR: 0.008) ... *(Total significant: 68. See string_terms.csv for full list.)*
- RCTM: Downstream signaling events of B Cell Receptor (BCR) (HSA-1168372) (FDR: 0.003); Cdc20:Phospho-APC/C mediated degradation of Cyclin A (HSA-174184) (FDR: 0.003); Regulation of APC/C activators between G1/S and early anaphase (HSA-176408) (FDR: 0.003); Fc epsilon receptor (FCERI) signaling (HSA-2454202) (FDR: 0.003); MAPK family signaling cascades (HSA-5683057) (FDR: 0.003) ... *(Total significant: 71. See string_terms.csv for full list.)*
- WikiPathways: PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (WP3844) (FDR: 0.012); Alzheimers disease and miRNA effects (WP2059) (FDR: 0.015); Synaptic signaling pathways associated with autism spectrum disorder (WP4539) (FDR: 0.015); Alzheimers disease (WP5124) (FDR: 0.015); PI3K-Akt signaling pathway (WP4172) (FDR: 0.020) ... *(Total significant: 15. See string_terms.csv for full list.)*
- HPO: Renal neoplasm (HP:0009726) (FDR: 0.005); Hemimegalencephaly (HP:0007206) (FDR: 0.006); Renal cell carcinoma (HP:0005584) (FDR: 0.007); Hamartoma (HP:0010566) (FDR: 0.009); Adenoma sebaceum (HP:0009720) (FDR: 0.010) ... *(Total significant: 23. See string_terms.csv for full list.)*
- NetworkNeighborAL: Spliceosomal snRNP complex, and mRNA cis splicing, via spliceosome (CL:2036) (FDR: 0.014); Coenzyme A biosynthesis (CL:11025) (FDR: 0.046); Precatalytic spliceosome, and U4/U6 x U5 tri-snRNP complex (CL:2038) (FDR: 0.046) *(Total significant: 3)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Anoikis (GO:0043276) (Adj. P: 0.007, Combined Score: 2410.75); Coenzyme A Biosynthetic Process (GO:0015937) (Adj. P: 0.007, Combined Score: 2013.35); Nucleoside Phosphate Biosynthetic Process (GO:1901293) (Adj. P: 0.001, Combined Score: 1849.83); Coenzyme A Metabolic Process (GO:0015936) (Adj. P: 0.014, Combined Score: 1060.46); Negative Regulation of Anoikis (GO:2000811) (Adj. P: 0.018, Combined Score: 808.91) ... *(Total significant: 18. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: 1-Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity (GO:0046934) (Adj. P: 0.046, Combined Score: 878.83); Supercoiled DNA Binding (GO:0097100) (Adj. P: 0.046, Combined Score: 878.83); BH Domain Binding (GO:0051400) (Adj. P: 0.046, Combined Score: 878.83); BH3 Domain Binding (GO:0051434) (Adj. P: 0.046, Combined Score: 878.83); 1-Phosphatidylinositol-4-Phosphate 3-Kinase Activity (GO:0035005) (Adj. P: 0.046, Combined Score: 677.12) ... *(Total significant: 23. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: MLL1 Complex (GO:0071339) (Adj. P: 0.014, Combined Score: 372.34); MLL1/2 Complex (GO:0044665) (Adj. P: 0.014, Combined Score: 356.13); Nucleus (GO:0005634) (Adj. P: 0.014, Combined Score: 30.26); Intracellular Membrane-Bounded Organelle (GO:0043231) (Adj. P: 0.014, Combined Score: 27.58) *(Total significant: 4)*
- Reactome_2022: Signaling By FLT3 ITD And TKD Mutants R-HSA-9703648 (Adj. P: 2.08e-04, Combined Score: 2611.27); Coenzyme A Biosynthesis R-HSA-196783 (Adj. P: 9.80e-04, Combined Score: 2410.75); Signaling By FGFR4 In Disease R-HSA-5655291 (Adj. P: 0.001, Combined Score: 1720.52); Signaling By PDGFRA Extracellular Domain Mutants R-HSA-9673770 (Adj. P: 0.001, Combined Score: 1496.45); FLT3 Signaling In Disease R-HSA-9682385 (Adj. P: 2.56e-04, Combined Score: 1127.52) ... *(Total significant: 303. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: G2-M Checkpoint (Adj. P: 0.036, Combined Score: 67.39) *(Total significant: 1)*
- Human_Phenotype_Ontology: Hamartoma of the eye (HP:0010568) (Adj. P: 0.006, Combined Score: 1177.53); Hamartoma (HP:0010566) (Adj. P: 0.001, Combined Score: 1021.16); Renal cell carcinoma (HP:0005584) (Adj. P: 0.001, Combined Score: 891.37); Visceral angiomatosis (HP:0100761) (Adj. P: 0.006, Combined Score: 879.86); Adenoma sebaceum (HP:0009720) (Adj. P: 0.006, Combined Score: 808.91) ... *(Total significant: 54. See enrichr_terms.csv for full list.)*
- OMIM_Disease: gastric cancer (Adj. P: 0.034, Combined Score: 295.52); colorectal cancer (Adj. P: 0.011, Combined Score: 251.88); ovarian cancer (Adj. P: 0.034, Combined Score: 236.40); hypogonadism (Adj. P: 0.034, Combined Score: 195.39); thyroid carcinoma (Adj. P: 0.034, Combined Score: 165.44) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 2 (k=11)

This cluster contains 4 genes.
Average Silhouette Score: 0.106.
Highest expression is observed in: Nerve - Tibial, Spleen, Thyroid, Adrenal Gland, Lung.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Galactose Catabolic Process (GO:0019388) (Adj. P: 0.015, Combined Score: 6128.34); Galactose Metabolic Process (GO:0006012) (Adj. P: 0.015, Combined Score: 4600.93); AMP Metabolic Process (GO:0046033) (Adj. P: 0.015, Combined Score: 4077.19); Purine Ribonucleoside Monophosphate Metabolic Process (GO:0009167) (Adj. P: 0.015, Combined Score: 3653.70); Nucleotide-Sugar Metabolic Process (GO:0009225) (Adj. P: 0.015, Combined Score: 3012.37) ... *(Total significant: 28. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Adenylate Kinase Activity (GO:0004017) (Adj. P: 0.008, Combined Score: 8963.74); Filamin Binding (GO:0031005) (Adj. P: 0.008, Combined Score: 4600.93); Nucleoside Monophosphate Kinase Activity (GO:0050145) (Adj. P: 0.008, Combined Score: 2204.79); Nucleobase-Containing Compound Kinase Activity (GO:0019205) (Adj. P: 0.008, Combined Score: 1935.63); Phosphotransferase Activity, Phosphate Group as Acceptor (GO:0016776) (Adj. P: 0.008, Combined Score: 1400.90) *(Total significant: 5)*
- Reactome_2022: Diseases Associated With Glycosylation Precursor Biosynthesis R-HSA-5609975 (Adj. P: 0.024, Combined Score: 2764.28) *(Total significant: 1)*
- MSigDB_Hallmark_2020: UV Response Dn (Adj. P: 0.039, Combined Score: 164.66); DNA Repair (Adj. P: 0.039, Combined Score: 156.19); Glycolysis (Adj. P: 0.039, Combined Score: 107.24) *(Total significant: 3)*
- Human_Phenotype_Ontology: Chronic hepatic failure (HP:0100626) (Adj. P: 0.014, Combined Score: 6128.34); Premature ovarian failure (HP:0008209) (Adj. P: 0.014, Combined Score: 2366.46); Hypergonadotropic hypogonadism (HP:0000815) (Adj. P: 0.014, Combined Score: 1629.20); Sepsis (HP:0100806) (Adj. P: 0.022, Combined Score: 625.39); Metabolic acidosis (HP:0001942) (Adj. P: 0.022, Combined Score: 488.52) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 3 (k=11)

This cluster contains 13 genes.
Average Silhouette Score: 0.054.
Highest expression is observed in: Whole Blood, Spleen, Lung, Cells - EBV-transformed lymphocytes, Small Intestine - Terminal Ileum.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Cytoplasm (GOCC:0005737) (FDR: 0.026) *(Total significant: 1)*
- Function: Adenosine-diphosphatase activity (GO:0043262) (FDR: 0.030) *(Total significant: 1)*
- TISSUES: Digestive gland (BTO:0000345) (FDR: 0.031); Liver (BTO:0000759) (FDR: 0.031) *(Total significant: 2)*
- Keyword: Coenzyme A biosynthesis (KW-0173) (FDR: 0.007) *(Total significant: 1)*
- KEGG: Purine metabolism (hsa00230) (FDR: 0.026); Pantothenate and CoA biosynthesis (hsa00770) (FDR: 0.026); Metabolic pathways (hsa01100) (FDR: 0.026); Pyrimidine metabolism (hsa00240) (FDR: 0.047); Notch signaling pathway (hsa04330) (FDR: 0.047) *(Total significant: 5)*
- RCTM: Coenzyme A biosynthesis (HSA-196783) (FDR: 0.041) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Coenzyme A Biosynthetic Process (GO:0015937) (Adj. P: 0.004, Combined Score: 5800.00); Coenzyme A Metabolic Process (GO:0015936) (Adj. P: 0.005, Combined Score: 3102.38); Negative Regulation of Glial Cell Proliferation (GO:0060253) (Adj. P: 0.030, Combined Score: 2385.60); Pericardium Morphogenesis (GO:0003344) (Adj. P: 0.030, Combined Score: 2385.60); Venous Blood Vessel Morphogenesis (GO:0048845) (Adj. P: 0.030, Combined Score: 2385.60) ... *(Total significant: 232. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Adenylate Kinase Activity (GO:0004017) (Adj. P: 0.041, Combined Score: 1847.77); Serine-Type Exopeptidase Activity (GO:0070008) (Adj. P: 0.041, Combined Score: 1847.77); UDP Phosphatase Activity (GO:0045134) (Adj. P: 0.041, Combined Score: 1251.42); GDP Phosphatase Activity (GO:0004382) (Adj. P: 0.041, Combined Score: 1070.48); FMN Binding (GO:0010181) (Adj. P: 0.041, Combined Score: 932.06) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- Reactome_2022: Coenzyme A Biosynthesis R-HSA-196783 (Adj. P: 0.003, Combined Score: 6918.95); Defective LFNG Causes SCDO3 R-HSA-5083630 (Adj. P: 0.030, Combined Score: 2385.60); FBXW7 Mutants And NOTCH1 In Cancer R-HSA-2644605 (Adj. P: 0.030, Combined Score: 2385.60); Vitamin B5 (Pantothenate) Metabolism R-HSA-199220 (Adj. P: 0.003, Combined Score: 2384.53); MECP2 Regulates Neuronal Receptors And Channels R-HSA-9022699 (Adj. P: 0.003, Combined Score: 2208.73) ... *(Total significant: 47. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Partial duplication of thumb phalanx (HP:0009944) (Adj. P: 0.042, Combined Score: 1251.42); Short 1st metacarpal (HP:0010034) (Adj. P: 0.042, Combined Score: 1251.42); Abnormal tarsal ossification (HP:0008369) (Adj. P: 0.042, Combined Score: 1251.42); Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) (Adj. P: 0.042, Combined Score: 1251.42); Broad metatarsal (HP:0001783) (Adj. P: 0.042, Combined Score: 1251.42) ... *(Total significant: 88. See enrichr_terms.csv for full list.)*
- OMIM_Disease: psoriasis (Adj. P: 0.026, Combined Score: 735.02); myocardial infarction (Adj. P: 0.026, Combined Score: 507.12); alzheimer disease (Adj. P: 0.028, Combined Score: 272.01); diabetes (Adj. P: 0.050, Combined Score: 68.24); leukemia (Adj. P: 0.050, Combined Score: 64.75) *(Total significant: 5)*

Top Genes (by silhouette):

Cluster 4 (k=11)

This cluster contains 22 genes.
Average Silhouette Score: 0.048.
Highest expression is observed in: Cells - Cultured fibroblasts, Artery - Aorta, Artery - Tibial, Fallopian Tube, Uterus.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Proteasome complex (GOCC:0000502) (FDR: 0.002); Methyltransferase complex (GOCC:0034708) (FDR: 0.006); Catalytic complex (GOCC:1902494) (FDR: 0.023); Proteasome regulatory particle, base subcomplex (GOCC:0008540) (FDR: 0.025); Proteasome core complex, beta-subunit complex (GOCC:0019774) (FDR: 0.030) *(Total significant: 5)*
- Component: Proteasome complex (GO:0000502) (FDR: 0.002); Proteasome regulatory particle, base subcomplex (GO:0008540) (FDR: 0.033); Proteasome core complex, beta-subunit complex (GO:0019774) (FDR: 0.038) *(Total significant: 3)*
- Keyword: Proteasome (KW-0647) (FDR: 2.80e-04); Nucleotide metabolism (KW-0546) (FDR: 0.002) *(Total significant: 2)*
- KEGG: Proteasome (hsa03050) (FDR: 6.74e-05); Prion disease (hsa05020) (FDR: 0.002); Huntington disease (hsa05016) (FDR: 0.002); Spinocerebellar ataxia (hsa05017) (FDR: 0.002); Pyrimidine metabolism (hsa00240) (FDR: 0.002) ... *(Total significant: 9. See string_terms.csv for full list.)*
- RCTM: Regulation of RAS by GAPs (HSA-5658442) (FDR: 3.23e-05); HIV Infection (HSA-162906) (FDR: 2.00e-04); Activation of NF-kappaB in B cells (HSA-1169091) (FDR: 2.50e-04); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (HSA-1234176) (FDR: 2.50e-04); ER-Phagosome pathway (HSA-1236974) (FDR: 2.50e-04) ... *(Total significant: 70. See string_terms.csv for full list.)*
- WikiPathways: Proteasome degradation (WP183) (FDR: 6.20e-04) *(Total significant: 1)*
- NetworkNeighborAL: Mixed, incl. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha, and Ubiquitin conjugating enzyme activity (CL:3694) (FDR: 8.40e-04); Proteasome (CL:3706) (FDR: 8.40e-04); Proteasome, subunit alpha/beta, and Proteasome regulatory particle, base subcomplex (CL:3709) (FDR: 8.40e-04); Proteasome regulatory particle, base subcomplex, and Proteasome alpha-type subunit (CL:3710) (FDR: 0.024); Nucleoside diphosphate kinase, active site, and dGDP metabolic process (CL:10686) (FDR: 0.032) ... *(Total significant: 6. See string_terms.csv for full list.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulatory ncRNA-mediated Gene Silencing (GO:0031047) (Adj. P: 0.035, Combined Score: 409.88); Positive Regulation of Proteolysis Involved in Protein Catabolic Process (GO:1903052) (Adj. P: 0.035, Combined Score: 369.28); Positive Regulation of Protein Catabolic Process (GO:0045732) (Adj. P: 0.017, Combined Score: 283.99); Regulation of Stem Cell Population Maintenance (GO:2000036) (Adj. P: 0.042, Combined Score: 234.95); Regulation of Proteasomal Protein Catabolic Process (GO:0061136) (Adj. P: 0.042, Combined Score: 234.95) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Nucleoside Diphosphate Kinase Activity (GO:0004550) (Adj. P: 0.006, Combined Score: 1525.49); lncRNA Binding (GO:0106222) (Adj. P: 0.027, Combined Score: 1237.70); DNA-methyltransferase Activity (GO:0009008) (Adj. P: 0.027, Combined Score: 1237.70); Potassium Channel Inhibitor Activity (GO:0019870) (Adj. P: 0.027, Combined Score: 955.53); RNA Polymerase II C-terminal Domain Binding (GO:0099122) (Adj. P: 0.027, Combined Score: 955.53) ... *(Total significant: 24. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: RNA N6-methyladenosine Methyltransferase Complex (GO:0036396) (Adj. P: 0.042, Combined Score: 643.51); MLL1 Complex (GO:0071339) (Adj. P: 0.006, Combined Score: 542.55); MLL1/2 Complex (GO:0044665) (Adj. P: 0.006, Combined Score: 519.27); Cytoplasmic Vesicle Lumen (GO:0060205) (Adj. P: 0.042, Combined Score: 85.07); Ficolin-1-Rich Granule Lumen (GO:1904813) (Adj. P: 0.042, Combined Score: 79.24) *(Total significant: 5)*
- Reactome_2022: Regulation Of RAS By GAPs R-HSA-5658442 (Adj. P: 1.88e-06, Combined Score: 1822.56); Cross-presentation Of Soluble Exogenous Antigens (Endosomes) R-HSA-1236978 (Adj. P: 3.84e-06, Combined Score: 1549.53); Regulation Of Activated PAK-2p34 By Proteasome Mediated Degradation R-HSA-211733 (Adj. P: 3.84e-06, Combined Score: 1506.71); Regulation Of Ornithine Decarboxylase (ODC) R-HSA-350562 (Adj. P: 3.84e-06, Combined Score: 1465.92); GSK3B And BTRC:CUL1-mediated-degradation Of NFE2L2 R-HSA-9762114 (Adj. P: 3.84e-06, Combined Score: 1427.03) ... *(Total significant: 184. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: DNA Repair (Adj. P: 0.003, Combined Score: 158.98) *(Total significant: 1)*

Top Genes (by silhouette):

Cluster 5 (k=11)

This cluster contains 3 genes.
Average Silhouette Score: 0.236.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Cells - Cultured fibroblasts, Brain - Frontal Cortex (BA9), Esophagus - Mucosa, Brain - Anterior cingulate cortex (BA24).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Cell Population Proliferation (GO:0008285) (Adj. P: 6.21e-04, Combined Score: 700805.49); + Reg of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target (GO:0002860) (Adj. P: 0.010, Combined Score: 17982.86); Positive Regulation of Natural Killer Cell Mediated Immune Response to Tumor Cell (GO:0002857) (Adj. P: 0.010, Combined Score: 17982.86); Regulation of NK T Cell Activation (GO:0051133) (Adj. P: 0.010, Combined Score: 14021.17); Positive Regulation of Muscle Cell Apoptotic Process (GO:0010661) (Adj. P: 0.010, Combined Score: 14021.17) ... *(Total significant: 89. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: DNA Replication Origin Binding (GO:0003688) (Adj. P: 0.012, Combined Score: 5196.55); Nucleoside Diphosphate Kinase Activity (GO:0004550) (Adj. P: 0.012, Combined Score: 4739.66); Protein Serine/Threonine Kinase Binding (GO:0120283) (Adj. P: 0.012, Combined Score: 4351.69); DNA Nuclease Activity (GO:0004536) (Adj. P: 0.012, Combined Score: 3476.15); Ribosomal Small Subunit Binding (GO:0043024) (Adj. P: 0.012, Combined Score: 3252.89) ... *(Total significant: 19. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Late Endosome Lumen (GO:0031906) (Adj. P: 0.016, Combined Score: 9603.49); Endosome Lumen (GO:0031904) (Adj. P: 0.024, Combined Score: 2324.86) *(Total significant: 2)*
- Reactome_2022: CDC6 Association With ORC:origin Complex R-HSA-68689 (Adj. P: 0.021, Combined Score: 9603.49); Interleukin-35 Signaling R-HSA-8984722 (Adj. P: 0.021, Combined Score: 5741.92); Transcription Of E2F Targets Under Negative Control By DREAM Complex R-HSA-1362277 (Adj. P: 0.021, Combined Score: 3252.89); G0 And Early G1 R-HSA-1538133 (Adj. P: 0.021, Combined Score: 2116.29); G1/S-Specific Transcription R-HSA-69205 (Adj. P: 0.021, Combined Score: 1939.49) ... *(Total significant: 23. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Allograft Rejection (Adj. P: 0.002, Combined Score: 1624.59); DNA Repair (Adj. P: 0.030, Combined Score: 253.21); IL-2/STAT5 Signaling (Adj. P: 0.030, Combined Score: 176.07); G2-M Checkpoint (Adj. P: 0.030, Combined Score: 174.93); E2F Targets (Adj. P: 0.030, Combined Score: 174.93) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Birth length less than 3rd percentile (HP:0003561) (Adj. P: 0.010, Combined Score: 9603.49); Hypoplasia of the capital femoral epiphysis (HP:0003090) (Adj. P: 0.010, Combined Score: 8255.55); Abnormal pupillary function (HP:0007686) (Adj. P: 0.010, Combined Score: 8255.55); Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) (Adj. P: 0.010, Combined Score: 6403.33); Irregular epiphyses (HP:0010582) (Adj. P: 0.010, Combined Score: 6403.33) ... *(Total significant: 53. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 6 (k=11)

This cluster contains 6 genes.
Average Silhouette Score: -0.034.
Highest expression is observed in: Adipose - Subcutaneous, Cells - EBV-transformed lymphocytes, Spleen, Whole Blood, Lung.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- RCTM: MET activates RAP1 and RAC1 (HSA-8875555) (FDR: 0.014); Erythropoietin activates RAS (HSA-9027284) (FDR: 0.014); Regulation of signaling by CBL (HSA-912631) (FDR: 0.016); Downstream signal transduction (HSA-186763) (FDR: 0.016); Signalling to ERKs (HSA-187687) (FDR: 0.018) *(Total significant: 5)*
- WikiPathways: Hepatocyte growth factor receptor signaling (WP313) (FDR: 0.038); IL-3 signaling pathway (WP286) (FDR: 0.038); MET in type 1 papillary renal cell carcinoma (WP4205) (FDR: 0.038); Leptin signaling pathway (WP2034) (FDR: 0.045) *(Total significant: 4)*
- NetworkNeighborAL: Downstream signal transduction, and GRB2-associated-binding protein 1-4-like (CL:17509) (FDR: 0.048) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Relaxation of Cardiac Muscle (GO:1901897) (Adj. P: 0.017, Combined Score: 6499.56); Negative Regulation of Relaxation of Muscle (GO:1901078) (Adj. P: 0.017, Combined Score: 6499.56); Negative Regulation of Response to Food (GO:0032096) (Adj. P: 0.017, Combined Score: 5053.71); Adult Feeding Behavior (GO:0008343) (Adj. P: 0.017, Combined Score: 5053.71); Regulation of Natural Killer Cell Mediated Immunity (GO:0002715) (Adj. P: 0.017, Combined Score: 5053.71) ... *(Total significant: 133. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Neurotrophin TRK Receptor Binding (GO:0005167) (Adj. P: 0.020, Combined Score: 6499.56); Neurotrophin TRKA Receptor Binding (GO:0005168) (Adj. P: 0.020, Combined Score: 6499.56); cAMP Response Element Binding (GO:0035497) (Adj. P: 0.020, Combined Score: 2955.69); Peptide Hormone Receptor Binding (GO:0051428) (Adj. P: 0.020, Combined Score: 1847.77); cAMP Binding (GO:0030552) (Adj. P: 0.020, Combined Score: 1227.64) ... *(Total significant: 18. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Voltage-Gated Calcium Channel Complex (GO:0005891) (Adj. P: 0.038, Combined Score: 467.70); Calcium Channel Complex (GO:0034704) (Adj. P: 0.038, Combined Score: 333.96) *(Total significant: 2)*
- Reactome_2022: MET Activates RAP1 And RAC1 R-HSA-8875555 (Adj. P: 5.43e-04, Combined Score: 13767.08); Erythropoietin Activates RAS R-HSA-9027284 (Adj. P: 5.43e-04, Combined Score: 10945.74); Regulation Of Signaling By CBL R-HSA-912631 (Adj. P: 7.10e-04, Combined Score: 7103.11); MET Activates PTPN11 R-HSA-8865999 (Adj. P: 0.015, Combined Score: 6499.56); Activated NTRK2 Signals Thru PI3K R-HSA-9028335 (Adj. P: 0.015, Combined Score: 5053.71) ... *(Total significant: 162. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Cortical visual impairment (HP:0100704) (Adj. P: 0.020, Combined Score: 1422.78); Abnormal eating behavior (HP:0100738) (Adj. P: 0.020, Combined Score: 955.53); Clonus (HP:0002169) (Adj. P: 0.020, Combined Score: 677.12); Muscular hypotonia of the trunk (HP:0008936) (Adj. P: 0.028, Combined Score: 318.15); Hypoplasia of the corpus callosum (HP:0002079) (Adj. P: 0.043, Combined Score: 136.11) *(Total significant: 5)*
- OMIM_Disease: hypogonadism (Adj. P: 0.009, Combined Score: 1542.87); obesity (Adj. P: 0.009, Combined Score: 623.08) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 7 (k=11)

This cluster contains 7 genes.
Average Silhouette Score: -0.009.
Highest expression is observed in: Esophagus - Mucosa, Skin - Not Sun Exposed (Suprapubic), Skin - Sun Exposed (Lower leg), Vagina, Cervix - Ectocervix.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: cAMP Biosynthetic Process (GO:0006171) (Adj. P: 0.020, Combined Score: 2797.66); Coenzyme A Biosynthetic Process (GO:0015937) (Adj. P: 0.020, Combined Score: 2398.85); Regulation of Store-Operated Calcium Entry (GO:2001256) (Adj. P: 0.020, Combined Score: 2398.85); Actin Crosslink Formation (GO:0051764) (Adj. P: 0.020, Combined Score: 1852.16); Negative Regulation of calcineurin-NFAT Signaling Cascade (GO:0070885) (Adj. P: 0.020, Combined Score: 1852.16) ... *(Total significant: 49. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: DNA-methyltransferase Activity (GO:0009008) (Adj. P: 0.014, Combined Score: 5287.72); Serine-Type Exopeptidase Activity (GO:0070008) (Adj. P: 0.014, Combined Score: 4108.59); G Protein-Coupled Glutamate Receptor Binding (GO:0035256) (Adj. P: 0.014, Combined Score: 3338.15); Cadherin Binding Involved in Cell-Cell Adhesion (GO:0098641) (Adj. P: 0.024, Combined Score: 1066.85); Glutamate Receptor Binding (GO:0035254) (Adj. P: 0.024, Combined Score: 818.24) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: PAR Polarity Complex (GO:0120157) (Adj. P: 0.035, Combined Score: 5287.72); Cell-Cell Junction (GO:0005911) (Adj. P: 0.050, Combined Score: 133.03) *(Total significant: 2)*
- Reactome_2022: Coenzyme A Biosynthesis R-HSA-196783 (Adj. P: 0.039, Combined Score: 2797.66); SUMOylation Of DNA Methylation Proteins R-HSA-4655427 (Adj. P: 0.047, Combined Score: 1151.45); Vitamin B5 (Pantothenate) Metabolism R-HSA-199220 (Adj. P: 0.047, Combined Score: 1066.85); RHO GTPase Cycle R-HSA-9012999 (Adj. P: 0.020, Combined Score: 266.56); Signaling By Rho GTPases R-HSA-194315 (Adj. P: 0.021, Combined Score: 155.19) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Thick nail (HP:0001805) (Adj. P: 0.029, Combined Score: 2093.27); Chronic bronchitis (HP:0004469) (Adj. P: 0.029, Combined Score: 1657.40); Protruding tongue (HP:0010808) (Adj. P: 0.029, Combined Score: 1362.86); Milia (HP:0001056) (Adj. P: 0.029, Combined Score: 1362.86); Abnormality of the neuromuscular junction (HP:0003398) (Adj. P: 0.029, Combined Score: 1362.86) ... *(Total significant: 25. See enrichr_terms.csv for full list.)*
- OMIM_Disease: anomalies (Adj. P: 0.007, Combined Score: 1497.03); epidermolysis bullosa (Adj. P: 0.007, Combined Score: 1497.03); immunodeficiency (Adj. P: 0.010, Combined Score: 570.56) *(Total significant: 3)*

Top Genes (by silhouette):

Cluster 8 (k=11)

This cluster contains 2 genes.
Average Silhouette Score: 0.780.
Highest expression is observed in: Pancreas, Stomach, Testis, Adrenal Gland, Spleen.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Top Genes (by silhouette):

Cluster 9 (k=11)

This cluster contains 6 genes.
Average Silhouette Score: -0.024.
Highest expression is observed in: Liver, Stomach, Heart - Atrial Appendage, Heart - Left Ventricle, Colon - Transverse.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- KEGG: Metabolic pathways (hsa01100) (FDR: 0.004); Collecting duct acid secretion (hsa04966) (FDR: 0.004); Gastric acid secretion (hsa04971) (FDR: 0.022) *(Total significant: 3)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Monoatomic Anion Transport (GO:0044070) (Adj. P: 0.010, Combined Score: 6499.56); Nucleoside Diphosphate Metabolic Process (GO:0009132) (Adj. P: 0.010, Combined Score: 5053.71); L-methionine Salvage (GO:0071267) (Adj. P: 0.010, Combined Score: 5053.71); S-adenosylmethionine Metabolic Process (GO:0046500) (Adj. P: 0.010, Combined Score: 2580.41); Angiotensin-Activated Signaling Pathway (GO:0038166) (Adj. P: 0.010, Combined Score: 2580.41) ... *(Total significant: 26. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Arylesterase Activity (GO:0004064) (Adj. P: 0.008, Combined Score: 6499.56); P-type Potassium Transmembrane Transporter Activity (GO:0008556) (Adj. P: 0.008, Combined Score: 5053.71); UDP Phosphatase Activity (GO:0045134) (Adj. P: 0.008, Combined Score: 3445.29); S-methyltransferase Activity (GO:0008172) (Adj. P: 0.008, Combined Score: 2955.69); GDP Phosphatase Activity (GO:0004382) (Adj. P: 0.008, Combined Score: 2955.69) ... *(Total significant: 14. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Sodium:Potassium-Exchanging ATPase Complex (GO:0005890) (Adj. P: 0.008, Combined Score: 2955.69); Cation-Transporting ATPase Complex (GO:0090533) (Adj. P: 0.013, Combined Score: 649.09) *(Total significant: 2)*
- Reactome_2022: Choline Catabolism R-HSA-6798163 (Adj. P: 0.010, Combined Score: 5053.71); Erythrocytes Take Up Oxygen And Release Carbon Dioxide R-HSA-1247673 (Adj. P: 0.010, Combined Score: 4108.59); Phosphate Bond Hydrolysis By NTPDase Proteins R-HSA-8850843 (Adj. P: 0.010, Combined Score: 3445.29); Erythrocytes Take Up Carbon Dioxide And Release Oxygen R-HSA-1237044 (Adj. P: 0.010, Combined Score: 2284.21); Reversible Hydration Of Carbon Dioxide R-HSA-1475029 (Adj. P: 0.010, Combined Score: 2044.88) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Increased density of long bones (HP:0006392) (Adj. P: 0.023, Combined Score: 3445.29); Paralysis (HP:0003470) (Adj. P: 0.023, Combined Score: 1542.87); Renal tubular acidosis (HP:0001947) (Adj. P: 0.023, Combined Score: 1227.64); Basal ganglia calcification (HP:0002135) (Adj. P: 0.023, Combined Score: 1076.21); Hepatosplenomegaly (HP:0001433) (Adj. P: 0.023, Combined Score: 814.75) ... *(Total significant: 15. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 10 (k=11)

This cluster contains 11 genes.
Average Silhouette Score: 0.305.
Highest expression is observed in: Brain - Frontal Cortex (BA9), Brain - Cortex, Brain - Anterior cingulate cortex (BA24), Brain - Hippocampus, Brain - Nucleus accumbens (basal ganglia).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Postsynaptic density (GOCC:0014069) (FDR: 3.85e-06); Cell junction (GOCC:0030054) (FDR: 3.85e-06); Synapse (GOCC:0045202) (FDR: 3.85e-06) *(Total significant: 3)*
- Process: Regulation of nervous system process (GO:0031644) (FDR: 1.70e-04); Modulation of chemical synaptic transmission (GO:0050804) (FDR: 4.00e-04); Regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) (FDR: 8.90e-04); Chemical synaptic transmission (GO:0007268) (FDR: 0.005) *(Total significant: 4)*
- Component: Postsynaptic density (GO:0014069) (FDR: 2.26e-07); Synapse (GO:0045202) (FDR: 2.32e-05); Glutamatergic synapse (GO:0098978) (FDR: 1.80e-04); Anchoring junction (GO:0070161) (FDR: 0.007); Somatodendritic compartment (GO:0036477) (FDR: 0.012) *(Total significant: 5)*
- DISEASES: Autosomal dominant cerebellar ataxia (DOID:1441) (FDR: 0.050) *(Total significant: 1)*
- Keyword: Synapse (KW-0770) (FDR: 0.001); Spinocerebellar ataxia (KW-0950) (FDR: 0.001); Cell junction (KW-0965) (FDR: 0.001) *(Total significant: 3)*
- KEGG: Adrenergic signaling in cardiomyocytes (hsa04261) (FDR: 0.022); Hippo signaling pathway (hsa04390) (FDR: 0.022); Tight junction (hsa04530) (FDR: 0.022); Long-term potentiation (hsa04720) (FDR: 0.049); Amphetamine addiction (hsa05031) (FDR: 0.049) ... *(Total significant: 6. See string_terms.csv for full list.)*
- InterPro: SAPAP family (IPR005026) (FDR: 5.19e-05) *(Total significant: 1)*
- Pfam: Guanylate-kinase-associated protein (GKAP) protein (PF03359) (FDR: 1.67e-05) *(Total significant: 1)*
- PMID: (2013) CaMKII regulates diacylglycerol lipase-alpha and striatal endocannabinoid signaling. (PMID:23502535) (FDR: 1.48e-06); (2021) mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving. (PMID:33444640) (FDR: 2.54e-06); (2022) Deep Single-Cell-Type Proteome Profiling of Mouse Brain by Nonsurgical AAV-Mediated Proximity Labeling. (PMID:35315655) (FDR: 7.53e-06); (2021) Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimers disease. (PMID:34326412) (FDR: 7.53e-06); (2021) Synaptic Protein Phosphorylation Networks Are Associated With Electroacupuncture-Induced Circadian Control in the Suprachiasmatic Nucleus. (PMID:34976011) (FDR: 2.32e-05) ... *(Total significant: 67. See string_terms.csv for full list.)*
- RCTM: Neurexins and neuroligins (HSA-6794361) (FDR: 2.50e-07); Neuronal System (HSA-112316) (FDR: 6.21e-07); Unblocking of NMDA receptors, glutamate binding and activation (HSA-438066) (FDR: 0.037); Ras activation upon Ca2+ influx through NMDA receptor (HSA-442982) (FDR: 0.037); Negative regulation of NMDA receptor-mediated neuronal transmission (HSA-9617324) (FDR: 0.037) ... *(Total significant: 6. See string_terms.csv for full list.)*
- WikiPathways: Disruption of postsynaptic signaling by CNV (WP4875) (FDR: 2.68e-06); Fragile X syndrome (WP4549) (FDR: 0.015) *(Total significant: 2)*
- HPO: Alzheimers disease biomarker measurement (EFO:0006514) (FDR: 0.021) *(Total significant: 1)*
- NetworkNeighborAL: Neurexins and neuroligins (CL:22982) (FDR: 2.36e-08); Neurexins and neuroligins (CL:22984) (FDR: 8.92e-07); Vocalization behavior, and Homer family (CL:22986) (FDR: 0.032) *(Total significant: 3)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Positive Regulation of T-helper 2 Cell Differentiation (GO:0045630) (Adj. P: 0.030, Combined Score: 2946.37); Regulation of Mitochondrial Membrane Permeability Involved in Apoptotic Process (GO:1902108) (Adj. P: 0.030, Combined Score: 2946.37); Modulation of Chemical Synaptic Transmission (GO:0050804) (Adj. P: 2.88e-07, Combined Score: 2911.35); Positive Regulation of Interleukin-5 Production (GO:0032754) (Adj. P: 0.030, Combined Score: 2284.21); Regulation of Trans-Synaptic Signaling (GO:0099177) (Adj. P: 1.01e-04, Combined Score: 2232.29) ... *(Total significant: 75. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Adenylate Cyclase Inhibiting G Protein-Coupled Glutamate Receptor Activity (GO:0001640) (Adj. P: 0.037, Combined Score: 1549.44); Diacylglycerol-Dependent Serine/Threonine Kinase Activity (GO:0004697) (Adj. P: 0.037, Combined Score: 822.99); Glutamate Receptor Activity (GO:0008066) (Adj. P: 0.037, Combined Score: 583.76); Postsynaptic Neurotransmitter Receptor Activity (GO:0098960) (Adj. P: 0.037, Combined Score: 506.56); Lysophospholipase Activity (GO:0004622) (Adj. P: 0.037, Combined Score: 445.92) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: PAR Polarity Complex (GO:0120157) (Adj. P: 0.021, Combined Score: 2946.37); Neuronal Dense Core Vesicle (GO:0098992) (Adj. P: 0.021, Combined Score: 2946.37); G Protein-Coupled Receptor Dimeric Complex (GO:0038037) (Adj. P: 0.021, Combined Score: 2284.21); Neuron to Neuron Synapse (GO:0098984) (Adj. P: 0.025, Combined Score: 1326.33); Glutamatergic Synapse (GO:0098978) (Adj. P: 6.19e-04, Combined Score: 812.85) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- Reactome_2022: Neurexins And Neuroligins R-HSA-6794361 (Adj. P: 1.04e-06, Combined Score: 3818.44); Protein-protein Interactions At Synapses R-HSA-6794362 (Adj. P: 3.68e-06, Combined Score: 2166.26); Neuronal System R-HSA-112316 (Adj. P: 1.04e-06, Combined Score: 1094.24); Opioid Signaling R-HSA-111885 (Adj. P: 0.025, Combined Score: 353.94) *(Total significant: 4)*
- Human_Phenotype_Ontology: Sensorimotor neuropathy (HP:0007141) (Adj. P: 3.21e-04, Combined Score: 4339.90); Dysdiadochokinesis (HP:0002075) (Adj. P: 3.58e-04, Combined Score: 2602.87); Dysmetria (HP:0001310) (Adj. P: 5.20e-05, Combined Score: 2362.47); Abnormality of saccadic eye movements (HP:0000570) (Adj. P: 7.61e-04, Combined Score: 1372.44); Action tremor (HP:0002345) (Adj. P: 0.016, Combined Score: 1326.33) ... *(Total significant: 22. See enrichr_terms.csv for full list.)*
- OMIM_Disease: spinocerebellar ataxia (Adj. P: 0.033, Combined Score: 216.36); ataxia (Adj. P: 0.033, Combined Score: 115.73) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 11 (k=11)

This cluster contains 11 genes.
Average Silhouette Score: 0.035.
Highest expression is observed in: Brain - Cerebellum, Brain - Cerebellar Hemisphere, Brain - Nucleus accumbens (basal ganglia), Brain - Frontal Cortex (BA9), Brain - Cortex.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Process: Neuron cell-cell adhesion (GO:0007158) (FDR: 0.002); S-adenosylmethionine cycle (GO:0033353) (FDR: 0.047); Terminal button organization (GO:0072553) (FDR: 0.047); Postsynaptic density protein 95 clustering (GO:0097119) (FDR: 0.047); Positive regulation of secretion by cell (GO:1903532) (FDR: 0.047) ... *(Total significant: 9. See string_terms.csv for full list.)*
- Component: GABA-ergic synapse (GO:0098982) (FDR: 0.021); Receptor complex (GO:0043235) (FDR: 0.037); Inhibitory synapse (GO:0060077) (FDR: 0.037); Spanning component of membrane (GO:0089717) (FDR: 0.037); Integral component of postsynaptic membrane (GO:0099055) (FDR: 0.037) ... *(Total significant: 6. See string_terms.csv for full list.)*
- Function: Adenosylhomocysteinase activity (GO:0004013) (FDR: 0.014); Neurexin family protein binding (GO:0042043) (FDR: 0.042) *(Total significant: 2)*
- Keyword: One-carbon metabolism (KW-0554) (FDR: 0.040) *(Total significant: 1)*
- SMART: S-adenosyl-L-homocysteine hydrolase, NAD binding domain (SM00997) (FDR: 0.002) *(Total significant: 1)*
- InterPro: Adenosylhomocysteinase-like (IPR000043) (FDR: 0.020); Neuroligin (IPR000460) (FDR: 0.020); S-adenosyl-L-homocysteine hydrolase, NAD binding domain (IPR015878) (FDR: 0.020); S-adenosyl-L-homocysteine hydrolase, conserved site (IPR020082) (FDR: 0.020); Adenosylhomocysteinase-like superfamily (IPR042172) (FDR: 0.020) ... *(Total significant: 7. See string_terms.csv for full list.)*
- HPO: Alkaline phosphatase measurement (EFO:0004533) (FDR: 0.038) *(Total significant: 1)*
- NetworkNeighborAL: Mixed, incl. Folic acid-containing compound metabolic process, and Cysteine and methionine catabolism (CL:8941) (FDR: 0.023); Adenosylhomocysteinase-like, and Cystathioninuria (CL:9005) (FDR: 0.023) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Postsynaptic Density Protein 95 Clustering (GO:0097119) (Adj. P: 2.13e-04, Combined Score: 18956.85); Postsynaptic Membrane Assembly (GO:0097104) (Adj. P: 2.13e-04, Combined Score: 18956.85); Neuron Cell-Cell Adhesion (GO:0007158) (Adj. P: 1.05e-05, Combined Score: 11522.92); Postsynapse Assembly (GO:0099068) (Adj. P: 2.56e-04, Combined Score: 10714.53); Positive Regulation of Synaptic Transmission, GABAergic (GO:0032230) (Adj. P: 2.56e-04, Combined Score: 8715.63) ... *(Total significant: 154. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Neurexin Family Protein Binding (GO:0042043) (Adj. P: 4.57e-04, Combined Score: 6273.06); Non-Membrane Spanning Protein Tyrosine Phosphatase Activity (GO:0004726) (Adj. P: 0.041, Combined Score: 2946.37); UDP Phosphatase Activity (GO:0045134) (Adj. P: 0.041, Combined Score: 1549.44); GDP Phosphatase Activity (GO:0004382) (Adj. P: 0.041, Combined Score: 1326.33); Estrogen Response Element Binding (GO:0034056) (Adj. P: 0.041, Combined Score: 1155.57) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Symmetric Synapse (GO:0032280) (Adj. P: 0.015, Combined Score: 2946.37); G Protein-Coupled Receptor Dimeric Complex (GO:0038037) (Adj. P: 0.015, Combined Score: 2284.21); GABA-ergic Synapse (GO:0098982) (Adj. P: 0.002, Combined Score: 2024.14); Inhibitory Synapse (GO:0060077) (Adj. P: 0.015, Combined Score: 1852.16); Synaptic Membrane (GO:0097060) (Adj. P: 0.003, Combined Score: 955.88) ... *(Total significant: 12. See enrichr_terms.csv for full list.)*
- Reactome_2022: MET Activates PTPN11 R-HSA-8865999 (Adj. P: 0.049, Combined Score: 2946.37); STAT5 Activation R-HSA-9645135 (Adj. P: 0.049, Combined Score: 1852.16); Vitamin B2 (Riboflavin) Metabolism R-HSA-196843 (Adj. P: 0.049, Combined Score: 1852.16); Phosphate Bond Hydrolysis By NTPDase Proteins R-HSA-8850843 (Adj. P: 0.049, Combined Score: 1549.44); Netrin Mediated Repulsion Signals R-HSA-418886 (Adj. P: 0.049, Combined Score: 1549.44) ... *(Total significant: 70. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Failure to thrive in infancy (HP:0001531) (Adj. P: 0.002, Combined Score: 6273.06); Neuroblastic tumors (HP:0004376) (Adj. P: 0.002, Combined Score: 2024.14); Primitive neuroectodermal tumor (HP:0030065) (Adj. P: 0.002, Combined Score: 2024.14); Peripheral primitive neuroectodermal neoplasm (HP:0030067) (Adj. P: 0.002, Combined Score: 2024.14); Neuroblastoma (HP:0003006) (Adj. P: 0.002, Combined Score: 2024.14) ... *(Total significant: 122. See enrichr_terms.csv for full list.)*
- OMIM_Disease: thyroid carcinoma (Adj. P: 0.024, Combined Score: 583.76); hypertension (Adj. P: 0.024, Combined Score: 295.52); leukemia (Adj. P: 0.042, Combined Score: 81.93) *(Total significant: 3)*

Top Genes (by silhouette):

Resolution Visualizations (k=21)

Cluster 1 (k=21)

This cluster contains 10 genes.
Average Silhouette Score: 0.109.
Highest expression is observed in: Cells - Cultured fibroblasts, Cells - EBV-transformed lymphocytes, Uterus, Ovary, Cervix - Endocervix.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- DISEASES: Epidermal nevus (DOID:0111162) (FDR: 0.030) *(Total significant: 1)*
- KEGG: Human T-cell leukemia virus 1 infection (hsa05166) (FDR: 9.10e-04); Sphingolipid signaling pathway (hsa04071) (FDR: 0.004); Alzheimer disease (hsa05010) (FDR: 0.004); Spinocerebellar ataxia (hsa05017) (FDR: 0.004); Hepatitis C (hsa05160) (FDR: 0.004) ... *(Total significant: 71. See string_terms.csv for full list.)*
- RCTM: Cdc20:Phospho-APC/C mediated degradation of Cyclin A (HSA-174184) (FDR: 9.62e-05); Regulation of APC/C activators between G1/S and early anaphase (HSA-176408) (FDR: 9.62e-05); Mitotic Anaphase (HSA-68882) (FDR: 9.62e-05); Fc epsilon receptor (FCERI) signaling (HSA-2454202) (FDR: 9.78e-05); Separation of Sister Chromatids (HSA-2467813) (FDR: 3.40e-04) ... *(Total significant: 108. See string_terms.csv for full list.)*
- WikiPathways: Alzheimers disease and miRNA effects (WP2059) (FDR: 0.005); Alzheimers disease (WP5124) (FDR: 0.005); Relationship between inflammation, COX-2 and EGFR (WP4483) (FDR: 0.021); PI3K-AKT-mTOR signaling pathway and therapeutic opportunities (WP3844) (FDR: 0.022); Kisspeptin/kisspeptin receptor system in the ovary (WP4871) (FDR: 0.029) ... *(Total significant: 17. See string_terms.csv for full list.)*
- HPO: Neoplasm of the stomach (HP:0006753) (FDR: 0.033); Female reproductive system neoplasm (HP:0033020) (FDR: 0.033); Cranial asymmetry (HP:0000267) (FDR: 0.042); Cafe-au-lait spot (HP:0000957) (FDR: 0.042); Numerous nevi (HP:0001054) (FDR: 0.042) ... *(Total significant: 24. See string_terms.csv for full list.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Actin Filament Depolymerization (GO:0030835) (Adj. P: 0.039, Combined Score: 3326.77); Metaphase/Anaphase Transition of Mitotic Cell Cycle (GO:0007091) (Adj. P: 0.039, Combined Score: 3326.77); Nucleoside Phosphate Biosynthetic Process (GO:1901293) (Adj. P: 0.005, Combined Score: 2987.15); Metaphase/Anaphase Transition of Cell Cycle (GO:0044784) (Adj. P: 0.039, Combined Score: 2580.41); Nucleoside Triphosphate Metabolic Process (GO:0009141) (Adj. P: 0.039, Combined Score: 1751.86) ... *(Total significant: 66. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: 1-Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Activity (GO:0046934) (Adj. P: 0.021, Combined Score: 3326.77); Supercoiled DNA Binding (GO:0097100) (Adj. P: 0.021, Combined Score: 3326.77); 1-Phosphatidylinositol-4-Phosphate 3-Kinase Activity (GO:0035005) (Adj. P: 0.021, Combined Score: 2580.41); Metal-Dependent Deubiquitinase Activity (GO:0140492) (Adj. P: 0.021, Combined Score: 1751.86); 1-Phosphatidylinositol-3-Kinase Activity (GO:0016303) (Adj. P: 0.021, Combined Score: 1500.17) ... *(Total significant: 16. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Phosphatidylinositol 3-Kinase Complex, Class I (GO:0097651) (Adj. P: 0.026, Combined Score: 1751.86); Phosphatidylinositol 3-Kinase Complex, Class IA (GO:0005943) (Adj. P: 0.026, Combined Score: 1751.86); Protein Phosphatase Type 2A Complex (GO:0000159) (Adj. P: 0.042, Combined Score: 661.82); Anaphase-Promoting Complex (GO:0005680) (Adj. P: 0.042, Combined Score: 506.01); Protein Serine/Threonine Phosphatase Complex (GO:0008287) (Adj. P: 0.042, Combined Score: 321.69) ... *(Total significant: 12. See enrichr_terms.csv for full list.)*
- Reactome_2022: Signaling By FGFR4 In Disease R-HSA-5655291 (Adj. P: 1.46e-04, Combined Score: 7182.69); Signaling By PDGFRA Extracellular Domain Mutants R-HSA-9673770 (Adj. P: 1.49e-04, Combined Score: 6273.06); Constitutive Signaling By EGFRvIII R-HSA-5637810 (Adj. P: 2.16e-04, Combined Score: 4494.85); Signaling By ERBB2 ECD Mutants R-HSA-9665348 (Adj. P: 2.25e-04, Combined Score: 4094.01); Signaling By FLT3 ITD And TKD Mutants R-HSA-9703648 (Adj. P: 2.25e-04, Combined Score: 4094.01) ... *(Total significant: 311. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: G2-M Checkpoint (Adj. P: 0.008, Combined Score: 136.48); Myc Targets V1 (Adj. P: 0.008, Combined Score: 136.48) *(Total significant: 2)*
- Human_Phenotype_Ontology: Meningioma (HP:0002858) (Adj. P: 0.001, Combined Score: 3461.84); Uterine leiomyosarcoma (HP:0002891) (Adj. P: 0.001, Combined Score: 2791.90); Leiomyosarcoma (HP:0100243) (Adj. P: 0.001, Combined Score: 2791.90); Nephroblastoma (Wilms tumor) (HP:0002667) (Adj. P: 0.001, Combined Score: 2791.90); Embryonal renal neoplasm (HP:0011794) (Adj. P: 0.001, Combined Score: 2618.60) ... *(Total significant: 141. See enrichr_terms.csv for full list.)*
- OMIM_Disease: gastric cancer (Adj. P: 0.013, Combined Score: 1155.57); colorectal cancer (Adj. P: 0.001, Combined Score: 1136.48); ovarian cancer (Adj. P: 0.013, Combined Score: 932.06); thyroid carcinoma (Adj. P: 0.013, Combined Score: 661.82); lung cancer (Adj. P: 0.013, Combined Score: 506.01) ... *(Total significant: 6. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 2 (k=21)

This cluster contains 19 genes.
Average Silhouette Score: 0.095.
Highest expression is observed in: Testis, Nerve - Tibial, Ovary, Uterus, Cervix - Endocervix.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Nucleus (GOCC:0005634) (FDR: 9.80e-04); Nucleoplasm (GOCC:0005654) (FDR: 9.80e-04); Nuclear lumen (GOCC:0031981) (FDR: 0.002); Protein-containing complex (GOCC:0032991) (FDR: 0.002); Spliceosomal complex (GOCC:0005681) (FDR: 0.005) ... *(Total significant: 8. See string_terms.csv for full list.)*
- Component: Nuclear body (GO:0016604) (FDR: 0.012); Protein-containing complex (GO:0032991) (FDR: 0.012); Spliceosomal complex (GO:0005681) (FDR: 0.023); Ribonucleoprotein complex (GO:1990904) (FDR: 0.023); Nucleoplasm (GO:0005654) (FDR: 0.026) ... *(Total significant: 7. See string_terms.csv for full list.)*
- Keyword: mRNA processing (KW-0507) (FDR: 0.006); Spliceosome (KW-0747) (FDR: 0.006) *(Total significant: 2)*
- NetworkNeighborAL: Spliceosomal snRNP complex, and mRNA cis splicing, via spliceosome (CL:2036) (FDR: 0.002); Precatalytic spliceosome, and U4/U6 x U5 tri-snRNP complex (CL:2038) (FDR: 0.012) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Intrinsic Apoptotic Signaling Pathway in Response to DNA Damage (GO:1902230) (Adj. P: 0.018, Combined Score: 845.42); Primary Neural Tube Formation (GO:0014020) (Adj. P: 0.018, Combined Score: 727.05); Tube Closure (GO:0060606) (Adj. P: 0.018, Combined Score: 693.92); Neural Tube Closure (GO:0001843) (Adj. P: 0.018, Combined Score: 663.37); Positive Regulation of Transcription by RNA Polymerase II (GO:0045944) (Adj. P: 0.006, Combined Score: 122.73) ... *(Total significant: 6. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: BH Domain Binding (GO:0051400) (Adj. P: 0.044, Combined Score: 1484.80); BH3 Domain Binding (GO:0051434) (Adj. P: 0.044, Combined Score: 1484.80); Death Domain Binding (GO:0070513) (Adj. P: 0.048, Combined Score: 774.04); Histone H4K12 Acetyltransferase Activity (GO:0043997) (Adj. P: 0.048, Combined Score: 660.97); Histone H4K5 Acetyltransferase Activity (GO:0043995) (Adj. P: 0.048, Combined Score: 660.97) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Nuclear Stress Granule (GO:0097165) (Adj. P: 0.049, Combined Score: 927.70); MLL1 Complex (GO:0071339) (Adj. P: 0.007, Combined Score: 663.37); MLL1/2 Complex (GO:0044665) (Adj. P: 0.007, Combined Score: 635.11); Intracellular Membrane-Bounded Organelle (GO:0043231) (Adj. P: 0.017, Combined Score: 28.88); Nucleus (GO:0005634) (Adj. P: 0.017, Combined Score: 26.89) *(Total significant: 5)*
- OMIM_Disease: hypogonadism (Adj. P: 0.014, Combined Score: 337.32) *(Total significant: 1)*

Top Genes (by silhouette):

Cluster 3 (k=21)

This cluster contains 4 genes.
Average Silhouette Score: 0.038.
Highest expression is observed in: Nerve - Tibial, Spleen, Thyroid, Adrenal Gland, Lung.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Galactose Catabolic Process (GO:0019388) (Adj. P: 0.015, Combined Score: 6128.34); Galactose Metabolic Process (GO:0006012) (Adj. P: 0.015, Combined Score: 4600.93); AMP Metabolic Process (GO:0046033) (Adj. P: 0.015, Combined Score: 4077.19); Purine Ribonucleoside Monophosphate Metabolic Process (GO:0009167) (Adj. P: 0.015, Combined Score: 3653.70); Nucleotide-Sugar Metabolic Process (GO:0009225) (Adj. P: 0.015, Combined Score: 3012.37) ... *(Total significant: 28. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Adenylate Kinase Activity (GO:0004017) (Adj. P: 0.008, Combined Score: 8963.74); Filamin Binding (GO:0031005) (Adj. P: 0.008, Combined Score: 4600.93); Nucleoside Monophosphate Kinase Activity (GO:0050145) (Adj. P: 0.008, Combined Score: 2204.79); Nucleobase-Containing Compound Kinase Activity (GO:0019205) (Adj. P: 0.008, Combined Score: 1935.63); Phosphotransferase Activity, Phosphate Group as Acceptor (GO:0016776) (Adj. P: 0.008, Combined Score: 1400.90) *(Total significant: 5)*
- Reactome_2022: Diseases Associated With Glycosylation Precursor Biosynthesis R-HSA-5609975 (Adj. P: 0.024, Combined Score: 2764.28) *(Total significant: 1)*
- MSigDB_Hallmark_2020: UV Response Dn (Adj. P: 0.039, Combined Score: 164.66); DNA Repair (Adj. P: 0.039, Combined Score: 156.19); Glycolysis (Adj. P: 0.039, Combined Score: 107.24) *(Total significant: 3)*
- Human_Phenotype_Ontology: Chronic hepatic failure (HP:0100626) (Adj. P: 0.014, Combined Score: 6128.34); Premature ovarian failure (HP:0008209) (Adj. P: 0.014, Combined Score: 2366.46); Hypergonadotropic hypogonadism (HP:0000815) (Adj. P: 0.014, Combined Score: 1629.20); Sepsis (HP:0100806) (Adj. P: 0.022, Combined Score: 625.39); Metabolic acidosis (HP:0001942) (Adj. P: 0.022, Combined Score: 488.52) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 4 (k=21)

This cluster contains 5 genes.
Average Silhouette Score: 0.158.
Highest expression is observed in: Whole Blood, Spleen, Lung, Cells - EBV-transformed lymphocytes, Small Intestine - Terminal Ileum.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Glial Cell Proliferation (GO:0060253) (Adj. P: 0.012, Combined Score: 8352.53); Pericardium Morphogenesis (GO:0003344) (Adj. P: 0.012, Combined Score: 8352.53); Venous Blood Vessel Morphogenesis (GO:0048845) (Adj. P: 0.012, Combined Score: 8352.53); Cilium Disassembly (GO:0061523) (Adj. P: 0.012, Combined Score: 8352.53); Positive Regulation of Transcription of Notch Receptor Target (GO:0007221) (Adj. P: 0.012, Combined Score: 8352.53) ... *(Total significant: 196. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: MHC Class I Protein Complex (GO:0042612) (Adj. P: 0.033, Combined Score: 8352.53); MHC Protein Complex (GO:0042611) (Adj. P: 0.033, Combined Score: 1393.12); Lumenal Side of Endoplasmic Reticulum Membrane (GO:0098553) (Adj. P: 0.041, Combined Score: 777.86); Phagocytic Vesicle Membrane (GO:0030670) (Adj. P: 0.042, Combined Score: 469.79); ER to Golgi Transport Vesicle Membrane (GO:0012507) (Adj. P: 0.042, Combined Score: 405.46) ... *(Total significant: 14. See enrichr_terms.csv for full list.)*
- Reactome_2022: Defective LFNG Causes SCDO3 R-HSA-5083630 (Adj. P: 0.023, Combined Score: 8352.53); FBXW7 Mutants And NOTCH1 In Cancer R-HSA-2644605 (Adj. P: 0.023, Combined Score: 8352.53); Pre-NOTCH Processing In Endoplasmic Reticulum R-HSA-1912399 (Adj. P: 0.026, Combined Score: 6499.56); Constitutive Signaling By NOTCH1 t(7;9)(NOTCH1:M1580 K2555) Translocation Mutant R-HSA-2660826 (Adj. P: 0.027, Combined Score: 5287.72); Endosomal/Vacuolar Pathway R-HSA-1236977 (Adj. P: 0.038, Combined Score: 2946.37) ... *(Total significant: 138. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Notch Signaling (Adj. P: 0.049, Combined Score: 777.86); Wnt-beta Catenin Signaling (Adj. P: 0.049, Combined Score: 554.88); Interferon Alpha Response (Adj. P: 0.049, Combined Score: 193.24); Apoptosis (Adj. P: 0.049, Combined Score: 100.06); Mitotic Spindle (Adj. P: 0.049, Combined Score: 75.50) ... *(Total significant: 12. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Aplasia cutis congenita (HP:0001057) (Adj. P: 0.018, Combined Score: 3326.77); Abnormality of the right ventricle (HP:0001707) (Adj. P: 0.018, Combined Score: 2946.37); Adactyly (HP:0009776) (Adj. P: 0.018, Combined Score: 2946.37); Absent hand (HP:0004050) (Adj. P: 0.018, Combined Score: 2173.55); Esophageal varix (HP:0002040) (Adj. P: 0.018, Combined Score: 1588.07) ... *(Total significant: 26. See enrichr_terms.csv for full list.)*
- OMIM_Disease: psoriasis (Adj. P: 0.006, Combined Score: 2638.91); leukemia (Adj. P: 0.019, Combined Score: 255.12) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 5 (k=21)

This cluster contains 2 genes.
Average Silhouette Score: 0.250.
Highest expression is observed in: Testis, Small Intestine - Terminal Ileum, Lung, Thyroid, Adipose - Subcutaneous.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Top Genes (by silhouette):

Cluster 6 (k=21)

This cluster contains 6 genes.
Average Silhouette Score: 0.110.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Thyroid, Spleen, Esophagus - Mucosa, Prostate.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Process: Carbohydrate derivative biosynthetic process (GO:1901137) (FDR: 0.002); Ribonucleotide metabolic process (GO:0009259) (FDR: 0.015); Coenzyme A biosynthetic process (GO:0015937) (FDR: 0.018); Organonitrogen compound biosynthetic process (GO:1901566) (FDR: 0.018); Purine ribonucleotide biosynthetic process (GO:0009152) (FDR: 0.029) *(Total significant: 5)*
- Function: Adenosine-diphosphatase activity (GO:0043262) (FDR: 0.006); Guanosine-diphosphatase activity (GO:0004382) (FDR: 0.011); Uridine-diphosphatase activity (GO:0045134) (FDR: 0.011) *(Total significant: 3)*
- Keyword: Coenzyme A biosynthesis (KW-0173) (FDR: 0.002) *(Total significant: 1)*
- KEGG: Purine metabolism (hsa00230) (FDR: 0.002); Pantothenate and CoA biosynthesis (hsa00770) (FDR: 0.002); Metabolic pathways (hsa01100) (FDR: 0.002); Pyrimidine metabolism (hsa00240) (FDR: 0.010) *(Total significant: 4)*
- RCTM: Coenzyme A biosynthesis (HSA-196783) (FDR: 0.008) *(Total significant: 1)*
- NetworkNeighborAL: Uridine-diphosphatase activity (CL:10592) (FDR: 0.010); Coenzyme A biosynthesis (CL:11025) (FDR: 0.010); Purine metabolism, and Pyrimidine metabolism (CL:10561) (FDR: 0.015) *(Total significant: 3)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Coenzyme A Biosynthetic Process (GO:0015937) (Adj. P: 2.51e-04, Combined Score: 18306.98); Coenzyme A Metabolic Process (GO:0015936) (Adj. P: 3.17e-04, Combined Score: 9904.86); Nucleoside Phosphate Biosynthetic Process (GO:1901293) (Adj. P: 3.97e-04, Combined Score: 6619.67); UDP Metabolic Process (GO:0046048) (Adj. P: 0.020, Combined Score: 6499.56); Purine-Containing Compound Biosynthetic Process (GO:0072522) (Adj. P: 4.80e-04, Combined Score: 4896.92) ... *(Total significant: 52. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Adenylate Kinase Activity (GO:0004017) (Adj. P: 0.020, Combined Score: 5053.71); UDP Phosphatase Activity (GO:0045134) (Adj. P: 0.020, Combined Score: 3445.29); GDP Phosphatase Activity (GO:0004382) (Adj. P: 0.020, Combined Score: 2955.69); FMN Binding (GO:0010181) (Adj. P: 0.020, Combined Score: 2580.41); RNA Polymerase II Core Promoter Sequence-Specific DNA Binding (GO:0000979) (Adj. P: 0.020, Combined Score: 1847.77) ... *(Total significant: 18. See enrichr_terms.csv for full list.)*
- Reactome_2022: Coenzyme A Biosynthesis R-HSA-196783 (Adj. P: 9.55e-05, Combined Score: 21777.60); Vitamin B5 (Pantothenate) Metabolism R-HSA-199220 (Adj. P: 3.09e-04, Combined Score: 7655.38); p75NTR Negatively Regulates Cell Cycle Via SC1 R-HSA-193670 (Adj. P: 0.023, Combined Score: 5053.71); MECP2 Regulates Transcription Of Neuronal Ligands R-HSA-9022702 (Adj. P: 0.024, Combined Score: 4108.59); Phosphate Bond Hydrolysis By NTPDase Proteins R-HSA-8850843 (Adj. P: 0.024, Combined Score: 3445.29) ... *(Total significant: 50. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Abnormal tarsal ossification (HP:0008369) (Adj. P: 0.019, Combined Score: 3445.29); Partial duplication of thumb phalanx (HP:0009944) (Adj. P: 0.019, Combined Score: 3445.29); Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026) (Adj. P: 0.019, Combined Score: 3445.29); Short 1st metacarpal (HP:0010034) (Adj. P: 0.019, Combined Score: 3445.29); Broad metatarsal (HP:0001783) (Adj. P: 0.019, Combined Score: 3445.29) ... *(Total significant: 84. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 7 (k=21)

This cluster contains 7 genes.
Average Silhouette Score: 0.110.
Highest expression is observed in: Prostate, Pituitary, Fallopian Tube, Artery - Aorta, Colon - Sigmoid.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- Keyword: Nucleotide metabolism (KW-0546) (FDR: 6.71e-05) *(Total significant: 1)*
- KEGG: Pyrimidine metabolism (hsa00240) (FDR: 2.80e-04); Purine metabolism (hsa00230) (FDR: 0.002); Drug metabolism - other enzymes (hsa00983) (FDR: 0.034) *(Total significant: 3)*
- SMART: These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity. (SM00562) (FDR: 0.006) *(Total significant: 1)*
- InterPro: Nucleoside diphosphate kinase (IPR001564) (FDR: 0.022); Nucleoside diphosphate kinase, active site (IPR023005) (FDR: 0.022); Nucleoside diphosphate kinase-like domain (IPR034907) (FDR: 0.022); Nucleoside diphosphate kinase-like domain superfamily (IPR036850) (FDR: 0.022) *(Total significant: 4)*
- NetworkNeighborAL: Pyrimidine metabolism, and Purine nucleoside monophosphate biosynthetic process (CL:10565) (FDR: 0.012); Nucleoside diphosphate kinase, active site, and dGDP metabolic process (CL:10686) (FDR: 0.012) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulatory ncRNA-mediated Heterochromatin Formation (GO:0031048) (Adj. P: 0.034, Combined Score: 3338.15); Nucleoside Triphosphate Metabolic Process (GO:0009141) (Adj. P: 0.034, Combined Score: 2797.66); Nucleoside Metabolic Process (GO:0009116) (Adj. P: 0.034, Combined Score: 2398.85); Regulation of RNA Metabolic Process (GO:0051252) (Adj. P: 0.034, Combined Score: 1852.16); Negative Regulation of Gene Expression via Chromosomal CpG Island Methylation (GO:0044027) (Adj. P: 0.034, Combined Score: 1852.16) ... *(Total significant: 33. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Nucleoside Diphosphate Kinase Activity (GO:0004550) (Adj. P: 2.67e-04, Combined Score: 7699.65); DNA-methyltransferase Activity (GO:0009008) (Adj. P: 0.010, Combined Score: 5287.72); lncRNA Binding (GO:0106222) (Adj. P: 0.010, Combined Score: 5287.72); Nucleobase-Containing Compound Kinase Activity (GO:0019205) (Adj. P: 2.78e-04, Combined Score: 4805.23); Potassium Channel Inhibitor Activity (GO:0019870) (Adj. P: 0.010, Combined Score: 4108.59) ... *(Total significant: 17. See enrichr_terms.csv for full list.)*
- Reactome_2022: Interconversion Of Nucleotide Di- And Triphosphates R-HSA-499943 (Adj. P: 0.002, Combined Score: 3114.47); PTK6 Regulates RHO GTPases, RAS GTPase And MAP Kinases R-HSA-8849471 (Adj. P: 0.040, Combined Score: 1497.03); mRNA Decay By 3 To 5 Exoribonuclease R-HSA-429958 (Adj. P: 0.040, Combined Score: 1151.45); SUMOylation Of DNA Methylation Proteins R-HSA-4655427 (Adj. P: 0.040, Combined Score: 1151.45); VEGFR2 Mediated Cell Proliferation R-HSA-5218921 (Adj. P: 0.040, Combined Score: 992.88) ... *(Total significant: 15. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: DNA Repair (Adj. P: 0.002, Combined Score: 363.25) *(Total significant: 1)*
- Human_Phenotype_Ontology: Epileptic encephalopathy (HP:0200134) (Adj. P: 0.023, Combined Score: 992.88); Torticollis (HP:0000473) (Adj. P: 0.023, Combined Score: 771.89); Craniofacial dystonia (HP:0012179) (Adj. P: 0.023, Combined Score: 597.17); Focal dystonia (HP:0004373) (Adj. P: 0.023, Combined Score: 546.01); Round face (HP:0000311) (Adj. P: 0.031, Combined Score: 282.07) *(Total significant: 5)*

Top Genes (by silhouette):

Cluster 8 (k=21)

This cluster contains 7 genes.
Average Silhouette Score: 0.064.
Highest expression is observed in: Cells - Cultured fibroblasts, Cells - EBV-transformed lymphocytes, Muscle - Skeletal, Testis, Artery - Tibial.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Proteasome complex (GOCC:0000502) (FDR: 0.003); Proteasome core complex, beta-subunit complex (GOCC:0019774) (FDR: 0.006); Nucleus (GOCC:0005634) (FDR: 0.019); Catalytic complex (GOCC:1902494) (FDR: 0.029); Protein-containing complex (GOCC:0032991) (FDR: 0.030) *(Total significant: 5)*
- Component: Proteasome complex (GO:0000502) (FDR: 0.002); Proteasome core complex, beta-subunit complex (GO:0019774) (FDR: 0.006); Catalytic complex (GO:1902494) (FDR: 0.018); Intracellular protein-containing complex (GO:0140535) (FDR: 0.024); Protein-containing complex (GO:0032991) (FDR: 0.034) *(Total significant: 5)*
- Function: Threonine-type endopeptidase activity (GO:0004298) (FDR: 0.042) *(Total significant: 1)*
- TISSUES: Embryo (BTO:0000379) (FDR: 0.006) *(Total significant: 1)*
- Keyword: Proteasome (KW-0647) (FDR: 4.80e-04); Threonine protease (KW-0888) (FDR: 0.006); Host-virus interaction (KW-0945) (FDR: 0.006) *(Total significant: 3)*
- KEGG: Proteasome (hsa03050) (FDR: 1.40e-04); Spinocerebellar ataxia (hsa05017) (FDR: 0.002); Parkinson disease (hsa05012) (FDR: 0.007); Prion disease (hsa05020) (FDR: 0.007); Huntington disease (hsa05016) (FDR: 0.008) ... *(Total significant: 7. See string_terms.csv for full list.)*
- InterPro: Peptidase T1A, proteasome beta-subunit (IPR000243) (FDR: 0.028); Proteasome beta-type subunit, conserved site (IPR016050) (FDR: 0.030); Proteasome B-type subunit (IPR023333) (FDR: 0.030); Proteasome, subunit alpha/beta (IPR001353) (FDR: 0.041) *(Total significant: 4)*
- RCTM: G1/S Transition (HSA-69206) (FDR: 1.60e-04); Regulation of expression of SLITs and ROBOs (HSA-9010553) (FDR: 1.60e-04); Activation of NF-kappaB in B cells (HSA-1169091) (FDR: 2.90e-04); Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (HSA-1234176) (FDR: 2.90e-04); ER-Phagosome pathway (HSA-1236974) (FDR: 2.90e-04) ... *(Total significant: 61. See string_terms.csv for full list.)*
- WikiPathways: Proteasome degradation (WP183) (FDR: 9.30e-04); Alzheimers disease and miRNA effects (WP2059) (FDR: 0.031); Alzheimers disease (WP5124) (FDR: 0.031) *(Total significant: 3)*
- NetworkNeighborAL: Proteasome (CL:3706) (FDR: 0.002); Proteasome, subunit alpha/beta, and Proteasome regulatory particle, base subcomplex (CL:3709) (FDR: 0.009) *(Total significant: 2)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Cap-Dependent Translational Initiation (GO:0002191) (Adj. P: 0.023, Combined Score: 5287.72); Regulation of mRNA 3'-End Processing (GO:0031440) (Adj. P: 0.023, Combined Score: 2797.66); Proteasome Assembly (GO:0043248) (Adj. P: 0.023, Combined Score: 2398.85); Endoplasmic Reticulum Membrane Organization (GO:0090158) (Adj. P: 0.023, Combined Score: 1852.16); Primary miRNA Processing (GO:0031053) (Adj. P: 0.023, Combined Score: 1657.40) ... *(Total significant: 47. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: RNA 7-Methylguanosine Cap Binding (GO:0000340) (Adj. P: 0.022, Combined Score: 1657.40); RNA Cap Binding (GO:0000339) (Adj. P: 0.022, Combined Score: 927.70); snRNA Binding (GO:0017069) (Adj. P: 0.037, Combined Score: 332.73); Endopeptidase Activity (GO:0004175) (Adj. P: 0.022, Combined Score: 136.01) *(Total significant: 4)*
- GO_Cellular_Component_2025: Intracellular Membrane-Bounded Organelle (GO:0043231) (Adj. P: 0.002, Combined Score: 899046.26); RNA N6-methyladenosine Methyltransferase Complex (GO:0036396) (Adj. P: 0.007, Combined Score: 2797.66); MLL1 Complex (GO:0071339) (Adj. P: 0.018, Combined Score: 523.28); Cytoplasmic Vesicle Lumen (GO:0060205) (Adj. P: 0.004, Combined Score: 502.37); MLL1/2 Complex (GO:0044665) (Adj. P: 0.018, Combined Score: 502.19) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- Reactome_2022: Cross-presentation Of Soluble Exogenous Antigens (Endosomes) R-HSA-1236978 (Adj. P: 5.08e-06, Combined Score: 4857.95); Regulation Of Activated PAK-2p34 By Proteasome Mediated Degradation R-HSA-211733 (Adj. P: 5.08e-06, Combined Score: 4731.60); Regulation Of Ornithine Decarboxylase (ODC) R-HSA-350562 (Adj. P: 5.08e-06, Combined Score: 4611.05); GSK3B And BTRC:CUL1-mediated-degradation Of NFE2L2 R-HSA-9762114 (Adj. P: 5.08e-06, Combined Score: 4495.92); Autodegradation Of E3 Ubiquitin Ligase COP1 R-HSA-349425 (Adj. P: 5.08e-06, Combined Score: 4495.92) ... *(Total significant: 184. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 9 (k=21)

This cluster contains 8 genes.
Average Silhouette Score: 0.068.
Highest expression is observed in: Brain - Cerebellar Hemisphere, Brain - Cerebellum, Artery - Tibial, Uterus, Artery - Aorta.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Trophoblast Cell Migration (GO:1901164) (Adj. P: 0.042, Combined Score: 4436.86); Positive Regulation of Glial Cell Migration (GO:1903977) (Adj. P: 0.042, Combined Score: 2797.66); Determination of Left/Right Asymmetry in Lateral Mesoderm (GO:0003140) (Adj. P: 0.042, Combined Score: 2343.48); Lateral Mesoderm Development (GO:0048368) (Adj. P: 0.042, Combined Score: 2008.48); Nodal Signaling Pathway (GO:0038092) (Adj. P: 0.045, Combined Score: 1549.44) ... *(Total significant: 34. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Morphogen Activity (GO:0016015) (Adj. P: 0.014, Combined Score: 3445.29); RNA Polymerase II C-terminal Domain Binding (GO:0099122) (Adj. P: 0.014, Combined Score: 3445.29); Activin Receptor Binding (GO:0070697) (Adj. P: 0.016, Combined Score: 2008.48); Peptide Hormone Receptor Binding (GO:0051428) (Adj. P: 0.016, Combined Score: 1251.42); SUMO Binding (GO:0032183) (Adj. P: 0.016, Combined Score: 1138.86) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Endoplasmic Reticulum Tubular Network (GO:0071782) (Adj. P: 0.049, Combined Score: 454.45); MLL1 Complex (GO:0071339) (Adj. P: 0.049, Combined Score: 435.44); MLL1/2 Complex (GO:0044665) (Adj. P: 0.049, Combined Score: 417.81) *(Total significant: 3)*
- Human_Phenotype_Ontology: Ankyloglossia (HP:0010296) (Adj. P: 0.034, Combined Score: 1751.86); Abdominal situs inversus (HP:0003363) (Adj. P: 0.034, Combined Score: 1751.86); Abnormality of abdominal situs (HP:0011620) (Adj. P: 0.034, Combined Score: 1751.86); Abnormality of oral frenula (HP:0000190) (Adj. P: 0.034, Combined Score: 1138.86); Truncus arteriosus (HP:0001660) (Adj. P: 0.034, Combined Score: 961.58) ... *(Total significant: 39. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 10 (k=21)

This cluster contains 3 genes.
Average Silhouette Score: 0.162.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Cells - Cultured fibroblasts, Brain - Frontal Cortex (BA9), Esophagus - Mucosa, Brain - Anterior cingulate cortex (BA24).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Negative Regulation of Cell Population Proliferation (GO:0008285) (Adj. P: 6.21e-04, Combined Score: 700805.49); + Reg of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target (GO:0002860) (Adj. P: 0.010, Combined Score: 17982.86); Positive Regulation of Natural Killer Cell Mediated Immune Response to Tumor Cell (GO:0002857) (Adj. P: 0.010, Combined Score: 17982.86); Regulation of NK T Cell Activation (GO:0051133) (Adj. P: 0.010, Combined Score: 14021.17); Positive Regulation of Muscle Cell Apoptotic Process (GO:0010661) (Adj. P: 0.010, Combined Score: 14021.17) ... *(Total significant: 89. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: DNA Replication Origin Binding (GO:0003688) (Adj. P: 0.012, Combined Score: 5196.55); Nucleoside Diphosphate Kinase Activity (GO:0004550) (Adj. P: 0.012, Combined Score: 4739.66); Protein Serine/Threonine Kinase Binding (GO:0120283) (Adj. P: 0.012, Combined Score: 4351.69); DNA Nuclease Activity (GO:0004536) (Adj. P: 0.012, Combined Score: 3476.15); Ribosomal Small Subunit Binding (GO:0043024) (Adj. P: 0.012, Combined Score: 3252.89) ... *(Total significant: 19. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Late Endosome Lumen (GO:0031906) (Adj. P: 0.016, Combined Score: 9603.49); Endosome Lumen (GO:0031904) (Adj. P: 0.024, Combined Score: 2324.86) *(Total significant: 2)*
- Reactome_2022: CDC6 Association With ORC:origin Complex R-HSA-68689 (Adj. P: 0.021, Combined Score: 9603.49); Interleukin-35 Signaling R-HSA-8984722 (Adj. P: 0.021, Combined Score: 5741.92); Transcription Of E2F Targets Under Negative Control By DREAM Complex R-HSA-1362277 (Adj. P: 0.021, Combined Score: 3252.89); G0 And Early G1 R-HSA-1538133 (Adj. P: 0.021, Combined Score: 2116.29); G1/S-Specific Transcription R-HSA-69205 (Adj. P: 0.021, Combined Score: 1939.49) ... *(Total significant: 23. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Allograft Rejection (Adj. P: 0.002, Combined Score: 1624.59); DNA Repair (Adj. P: 0.030, Combined Score: 253.21); IL-2/STAT5 Signaling (Adj. P: 0.030, Combined Score: 176.07); G2-M Checkpoint (Adj. P: 0.030, Combined Score: 174.93); E2F Targets (Adj. P: 0.030, Combined Score: 174.93) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Birth length less than 3rd percentile (HP:0003561) (Adj. P: 0.010, Combined Score: 9603.49); Hypoplasia of the capital femoral epiphysis (HP:0003090) (Adj. P: 0.010, Combined Score: 8255.55); Abnormal pupillary function (HP:0007686) (Adj. P: 0.010, Combined Score: 8255.55); Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) (Adj. P: 0.010, Combined Score: 6403.33); Irregular epiphyses (HP:0010582) (Adj. P: 0.010, Combined Score: 6403.33) ... *(Total significant: 53. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 11 (k=21)

This cluster contains 3 genes.
Average Silhouette Score: -0.015.
Highest expression is observed in: Cells - EBV-transformed lymphocytes, Spleen, Whole Blood, Lung, Pituitary.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- KEGG: Renal cell carcinoma (hsa05211) (FDR: 0.011); Neurotrophin signaling pathway (hsa04722) (FDR: 0.017); Insulin signaling pathway (hsa04910) (FDR: 0.017); Focal adhesion (hsa04510) (FDR: 0.025) *(Total significant: 4)*
- RCTM: MET activates RAP1 and RAC1 (HSA-8875555) (FDR: 0.003); Erythropoietin activates RAS (HSA-9027284) (FDR: 0.003); Regulation of signaling by CBL (HSA-912631) (FDR: 0.003); Downstream signal transduction (HSA-186763) (FDR: 0.003); Signalling to ERKs (HSA-187687) (FDR: 0.004) *(Total significant: 5)*
- WikiPathways: Hepatocyte growth factor receptor signaling (WP313) (FDR: 0.008); IL-3 signaling pathway (WP286) (FDR: 0.008); MET in type 1 papillary renal cell carcinoma (WP4205) (FDR: 0.008); Integrin-mediated cell adhesion (WP185) (FDR: 0.015); Androgen receptor network in prostate cancer (WP2263) (FDR: 0.015) ... *(Total significant: 8. See string_terms.csv for full list.)*
- NetworkNeighborAL: Downstream signal transduction, and GRB2-associated-binding protein 1-4-like (CL:17509) (FDR: 0.010) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: IMP Biosynthetic Process (GO:0006188) (Adj. P: 0.010, Combined Score: 11427.00); IMP Metabolic Process (GO:0046040) (Adj. P: 0.010, Combined Score: 8255.55); Nerve Growth Factor Signaling Pathway (GO:0038180) (Adj. P: 0.010, Combined Score: 8255.55); Rap Protein Signal Transduction (GO:0032486) (Adj. P: 0.010, Combined Score: 8255.55); AMP Metabolic Process (GO:0046033) (Adj. P: 0.010, Combined Score: 6403.33) ... *(Total significant: 54. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Neurotrophin TRK Receptor Binding (GO:0005167) (Adj. P: 0.004, Combined Score: 17982.86); Neurotrophin TRKA Receptor Binding (GO:0005168) (Adj. P: 0.004, Combined Score: 17982.86); Ephrin Receptor Binding (GO:0046875) (Adj. P: 0.012, Combined Score: 2718.11); Epidermal Growth Factor Receptor Binding (GO:0005154) (Adj. P: 0.012, Combined Score: 2116.29); Phosphotyrosine Residue Binding (GO:0001784) (Adj. P: 0.013, Combined Score: 1394.27) ... *(Total significant: 9. See enrichr_terms.csv for full list.)*
- Reactome_2022: MET Activates RAP1 And RAC1 R-HSA-8875555 (Adj. P: 1.03e-04, Combined Score: 62221.43); Erythropoietin Activates RAS R-HSA-9027284 (Adj. P: 1.03e-04, Combined Score: 49634.00); Regulation Of Signaling By CBL R-HSA-912631 (Adj. P: 1.35e-04, Combined Score: 32432.51); Signaling By Erythropoietin R-HSA-9006335 (Adj. P: 1.66e-04, Combined Score: 22509.23); MET Promotes Cell Motility R-HSA-8875878 (Adj. P: 1.66e-04, Combined Score: 18559.52) ... *(Total significant: 160. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: IL-6/JAK/STAT3 Signaling (Adj. P: 0.024, Combined Score: 502.79); PI3K/AKT/mTOR Signaling (Adj. P: 0.024, Combined Score: 397.49); Complement (Adj. P: 0.030, Combined Score: 174.93) *(Total significant: 3)*
- Human_Phenotype_Ontology: Cortical visual impairment (HP:0100704) (Adj. P: 0.013, Combined Score: 4018.42); Clonus (HP:0002169) (Adj. P: 0.013, Combined Score: 1939.49); Muscular hypotonia of the trunk (HP:0008936) (Adj. P: 0.016, Combined Score: 927.67); Hypoplasia of the corpus callosum (HP:0002079) (Adj. P: 0.023, Combined Score: 407.19); Cerebral cortical atrophy (HP:0002120) (Adj. P: 0.029, Combined Score: 227.69) *(Total significant: 5)*

Top Genes (by silhouette):

Cluster 12 (k=21)

This cluster contains 3 genes.
Average Silhouette Score: -0.011.
Highest expression is observed in: Adipose - Subcutaneous, Adipose - Visceral (Omentum), Breast - Mammary Tissue, Brain - Spinal cord (cervical c-1), Whole Blood.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- KEGG: AMPK signaling pathway (hsa04152) (FDR: 0.029); Parathyroid hormone synthesis, secretion and action (hsa04928) (FDR: 0.029); cAMP signaling pathway (hsa04024) (FDR: 0.037) *(Total significant: 3)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Relaxation of Cardiac Muscle (GO:1901897) (Adj. P: 0.010, Combined Score: 17982.86); Negative Regulation of Relaxation of Muscle (GO:1901078) (Adj. P: 0.010, Combined Score: 17982.86); Negative Regulation of Response to Food (GO:0032096) (Adj. P: 0.010, Combined Score: 14021.17); Adult Feeding Behavior (GO:0008343) (Adj. P: 0.010, Combined Score: 14021.17); Regulation of Natural Killer Cell Mediated Immunity (GO:0002715) (Adj. P: 0.010, Combined Score: 14021.17) ... *(Total significant: 98. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: cAMP Response Element Binding (GO:0035497) (Adj. P: 0.008, Combined Score: 8255.55); Peptide Hormone Receptor Binding (GO:0051428) (Adj. P: 0.008, Combined Score: 5196.55); cAMP Binding (GO:0030552) (Adj. P: 0.008, Combined Score: 3476.15); 3',5'-Cyclic-Nucleotide Phosphodiesterase Activity (GO:0004114) (Adj. P: 0.008, Combined Score: 3252.89); Hormone Receptor Binding (GO:0051427) (Adj. P: 0.008, Combined Score: 3252.89) ... *(Total significant: 11. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Voltage-Gated Calcium Channel Complex (GO:0005891) (Adj. P: 0.015, Combined Score: 1350.71); Calcium Channel Complex (GO:0034704) (Adj. P: 0.015, Combined Score: 972.53) *(Total significant: 2)*
- Reactome_2022: Signaling By Leptin R-HSA-2586552 (Adj. P: 0.010, Combined Score: 6403.33); Synthesis, Secretion, And Deacylation Of Ghrelin R-HSA-422085 (Adj. P: 0.010, Combined Score: 3252.89); Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) R-HSA-381771 (Adj. P: 0.010, Combined Score: 2877.37); DARPP-32 Events R-HSA-180024 (Adj. P: 0.010, Combined Score: 2443.77); Incretin Synthesis, Secretion, And Inactivation R-HSA-400508 (Adj. P: 0.010, Combined Score: 2443.77) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: DNA Repair (Adj. P: 0.030, Combined Score: 253.21); TNF-alpha Signaling via NF-kB (Adj. P: 0.030, Combined Score: 174.93); Interferon Gamma Response (Adj. P: 0.030, Combined Score: 174.93); Adipogenesis (Adj. P: 0.030, Combined Score: 174.93); Inflammatory Response (Adj. P: 0.030, Combined Score: 174.93) *(Total significant: 5)*
- Human_Phenotype_Ontology: Abnormal eating behavior (HP:0100738) (Adj. P: 0.003, Combined Score: 2718.11) *(Total significant: 1)*
- OMIM_Disease: hypogonadism (Adj. P: 0.004, Combined Score: 4351.69); obesity (Adj. P: 0.005, Combined Score: 1787.85) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 13 (k=21)

This cluster contains 3 genes.
Average Silhouette Score: 0.045.
Highest expression is observed in: Esophagus - Mucosa, Skin - Not Sun Exposed (Suprapubic), Skin - Sun Exposed (Lower leg), Vagina, Cervix - Ectocervix.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Store-Operated Calcium Entry (GO:2001256) (Adj. P: 0.018, Combined Score: 8255.55); Negative Regulation of Calcineurin-Mediated Signaling (GO:0106057) (Adj. P: 0.018, Combined Score: 6403.33); Actin Crosslink Formation (GO:0051764) (Adj. P: 0.018, Combined Score: 6403.33); Negative Regulation of calcineurin-NFAT Signaling Cascade (GO:0070885) (Adj. P: 0.018, Combined Score: 6403.33); G Protein-Coupled Glutamate Receptor Signaling Pathway (GO:0007216) (Adj. P: 0.018, Combined Score: 4739.66) ... *(Total significant: 41. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Serine-Type Exopeptidase Activity (GO:0070008) (Adj. P: 0.005, Combined Score: 14021.17); G Protein-Coupled Glutamate Receptor Binding (GO:0035256) (Adj. P: 0.005, Combined Score: 11427.00); Cadherin Binding Involved in Cell-Cell Adhesion (GO:0098641) (Adj. P: 0.007, Combined Score: 3729.25); Glutamate Receptor Binding (GO:0035254) (Adj. P: 0.007, Combined Score: 2877.37); Metallocarboxypeptidase Activity (GO:0004181) (Adj. P: 0.007, Combined Score: 2443.77) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- Reactome_2022: RHO GTPases Activate WASPs And WAVEs R-HSA-5663213 (Adj. P: 0.029, Combined Score: 1489.48); RND1 GTPase Cycle R-HSA-9696273 (Adj. P: 0.029, Combined Score: 1233.69); RND3 GTPase Cycle R-HSA-9696264 (Adj. P: 0.029, Combined Score: 1233.69); Golgi Associated Vesicle Biogenesis R-HSA-432722 (Adj. P: 0.029, Combined Score: 886.40); Neurexins And Neuroligins R-HSA-6794361 (Adj. P: 0.029, Combined Score: 848.32) ... *(Total significant: 18. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Androgen Response (Adj. P: 0.030, Combined Score: 422.55); KRAS Signaling Dn (Adj. P: 0.030, Combined Score: 174.93); Apical Junction (Adj. P: 0.030, Combined Score: 174.93); p53 Pathway (Adj. P: 0.030, Combined Score: 174.93); Estrogen Response Late (Adj. P: 0.030, Combined Score: 174.93) *(Total significant: 5)*
- Human_Phenotype_Ontology: Thick nail (HP:0001805) (Adj. P: 0.010, Combined Score: 7220.95); Abnormality of the neuromuscular junction (HP:0003398) (Adj. P: 0.010, Combined Score: 4739.66); Fatigable weakness (HP:0003473) (Adj. P: 0.010, Combined Score: 4739.66); Milia (HP:0001056) (Adj. P: 0.010, Combined Score: 4739.66); Ridged nail (HP:0001807) (Adj. P: 0.010, Combined Score: 4739.66) ... *(Total significant: 21. See enrichr_terms.csv for full list.)*
- OMIM_Disease: epidermolysis bullosa (Adj. P: 0.002, Combined Score: 5196.55) *(Total significant: 1)*

Top Genes (by silhouette):

Cluster 14 (k=21)

This cluster contains 4 genes.
Average Silhouette Score: 0.014.
Highest expression is observed in: Testis, Liver, Kidney - Medulla, Brain - Cerebellar Hemisphere, Skin - Sun Exposed (Lower leg).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: cAMP Biosynthetic Process (GO:0006171) (Adj. P: 0.021, Combined Score: 6128.34); Coenzyme A Biosynthetic Process (GO:0015937) (Adj. P: 0.021, Combined Score: 5264.00); cAMP Metabolic Process (GO:0046058) (Adj. P: 0.021, Combined Score: 3653.70); Coenzyme A Metabolic Process (GO:0015936) (Adj. P: 0.021, Combined Score: 3012.37); Cyclic Nucleotide Biosynthetic Process (GO:0009190) (Adj. P: 0.021, Combined Score: 2204.79) ... *(Total significant: 22. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: DNA-methyltransferase Activity (GO:0009008) (Adj. P: 0.007, Combined Score: 11508.86); Methyltransferase Activity (GO:0008168) (Adj. P: 0.025, Combined Score: 799.34); S-adenosylmethionine-dependent Methyltransferase Activity (GO:0008757) (Adj. P: 0.025, Combined Score: 555.66); Phosphotransferase Activity, Alcohol Group as Acceptor (GO:0016773) (Adj. P: 0.025, Combined Score: 353.55); Kinase Activity (GO:0016301) (Adj. P: 0.025, Combined Score: 300.03) *(Total significant: 5)*
- GO_Cellular_Component_2025: Nucleus (GO:0005634) (Adj. P: 0.018, Combined Score: 341378.54); Intracellular Membrane-Bounded Organelle (GO:0043231) (Adj. P: 0.020, Combined Score: 293521.08); PAR Polarity Complex (GO:0120157) (Adj. P: 0.010, Combined Score: 11508.86); Serine/Threonine Protein Kinase Complex (GO:1902554) (Adj. P: 0.030, Combined Score: 397.18); Bicellular Tight Junction (GO:0005923) (Adj. P: 0.030, Combined Score: 342.62) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- Reactome_2022: Coenzyme A Biosynthesis R-HSA-196783 (Adj. P: 0.031, Combined Score: 6128.34); SUMOylation Of DNA Methylation Proteins R-HSA-4655427 (Adj. P: 0.031, Combined Score: 2551.24); Vitamin B5 (Pantothenate) Metabolism R-HSA-199220 (Adj. P: 0.031, Combined Score: 2366.46); Tight Junction Interactions R-HSA-420029 (Adj. P: 0.031, Combined Score: 1174.65); DNA Methylation R-HSA-5334118 (Adj. P: 0.031, Combined Score: 1006.89) ... *(Total significant: 18. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Chronic bronchitis (HP:0004469) (Adj. P: 0.015, Combined Score: 3653.70); Protruding tongue (HP:0010808) (Adj. P: 0.015, Combined Score: 3012.37); T lymphocytopenia (HP:0005403) (Adj. P: 0.015, Combined Score: 2764.28); Abnormality of T cell number (HP:0011839) (Adj. P: 0.015, Combined Score: 2204.79); Flat face (HP:0012368) (Adj. P: 0.015, Combined Score: 1337.30) ... *(Total significant: 16. See enrichr_terms.csv for full list.)*
- OMIM_Disease: anomalies (Adj. P: 0.005, Combined Score: 3304.67); immunodeficiency (Adj. P: 0.006, Combined Score: 1278.76) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 15 (k=21)

This cluster contains 2 genes.
Average Silhouette Score: 0.773.
Highest expression is observed in: Pancreas, Stomach, Testis, Adrenal Gland, Spleen.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Top Genes (by silhouette):

Cluster 16 (k=21)

This cluster contains 2 genes.
Average Silhouette Score: 0.113.
Highest expression is observed in: Liver, Adipose - Visceral (Omentum), Kidney - Cortex, Whole Blood, Kidney - Medulla.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Top Genes (by silhouette):

Cluster 17 (k=21)

This cluster contains 3 genes.
Average Silhouette Score: 0.003.
Highest expression is observed in: Stomach, Colon - Transverse, Kidney - Medulla, Kidney - Cortex, Brain - Spinal cord (cervical c-1).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- KEGG: Collecting duct acid secretion (hsa04966) (FDR: 0.002); Gastric acid secretion (hsa04971) (FDR: 0.007); Metabolic pathways (hsa01100) (FDR: 0.043) *(Total significant: 3)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Regulation of Monoatomic Anion Transport (GO:0044070) (Adj. P: 0.005, Combined Score: 17982.86); Nucleoside Diphosphate Metabolic Process (GO:0009132) (Adj. P: 0.005, Combined Score: 14021.17); Angiotensin-Activated Signaling Pathway (GO:0038166) (Adj. P: 0.005, Combined Score: 7220.95); Carbon Dioxide Transport (GO:0015670) (Adj. P: 0.005, Combined Score: 6403.33); Cellular Response to Angiotensin (GO:1904385) (Adj. P: 0.005, Combined Score: 5741.92) ... *(Total significant: 22. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Arylesterase Activity (GO:0004064) (Adj. P: 0.004, Combined Score: 17982.86); P-type Potassium Transmembrane Transporter Activity (GO:0008556) (Adj. P: 0.004, Combined Score: 14021.17); UDP Phosphatase Activity (GO:0045134) (Adj. P: 0.004, Combined Score: 9603.49); GDP Phosphatase Activity (GO:0004382) (Adj. P: 0.004, Combined Score: 8255.55); Carbonate Dehydratase Activity (GO:0004089) (Adj. P: 0.004, Combined Score: 5741.92) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Sodium:Potassium-Exchanging ATPase Complex (GO:0005890) (Adj. P: 0.003, Combined Score: 8255.55); Cation-Transporting ATPase Complex (GO:0090533) (Adj. P: 0.004, Combined Score: 1860.86) *(Total significant: 2)*
- Reactome_2022: Erythrocytes Take Up Oxygen And Release Carbon Dioxide R-HSA-1247673 (Adj. P: 0.004, Combined Score: 11427.00); Phosphate Bond Hydrolysis By NTPDase Proteins R-HSA-8850843 (Adj. P: 0.004, Combined Score: 9603.49); Erythrocytes Take Up Carbon Dioxide And Release Oxygen R-HSA-1237044 (Adj. P: 0.004, Combined Score: 6403.33); Reversible Hydration Of Carbon Dioxide R-HSA-1475029 (Adj. P: 0.004, Combined Score: 5741.92); Nucleotide Catabolism R-HSA-8956319 (Adj. P: 0.009, Combined Score: 1541.63) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Fatty Acid Metabolism (Adj. P: 0.030, Combined Score: 236.95); UV Response Up (Adj. P: 0.030, Combined Score: 236.95); IL-2/STAT5 Signaling (Adj. P: 0.030, Combined Score: 176.07); Xenobiotic Metabolism (Adj. P: 0.030, Combined Score: 174.93); KRAS Signaling Up (Adj. P: 0.030, Combined Score: 174.93) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Increased density of long bones (HP:0006392) (Adj. P: 0.012, Combined Score: 9603.49); Paralysis (HP:0003470) (Adj. P: 0.012, Combined Score: 4351.69); Renal tubular acidosis (HP:0001947) (Adj. P: 0.012, Combined Score: 3476.15); Basal ganglia calcification (HP:0002135) (Adj. P: 0.012, Combined Score: 3054.59); Hepatosplenomegaly (HP:0001433) (Adj. P: 0.012, Combined Score: 2324.86) ... *(Total significant: 16. See enrichr_terms.csv for full list.)*

Top Genes (by silhouette):

Cluster 18 (k=21)

This cluster contains 1 genes.
Average Silhouette Score: 0.000.
Highest expression is observed in: Heart - Atrial Appendage, Heart - Left Ventricle, Muscle - Skeletal, Esophagus - Gastroesophageal Junction, Artery - Tibial.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Top Genes (by silhouette):

Cluster 19 (k=21)

This cluster contains 11 genes.
Average Silhouette Score: 0.275.
Highest expression is observed in: Brain - Frontal Cortex (BA9), Brain - Cortex, Brain - Anterior cingulate cortex (BA24), Brain - Hippocampus, Brain - Nucleus accumbens (basal ganglia).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Postsynaptic density (GOCC:0014069) (FDR: 3.85e-06); Cell junction (GOCC:0030054) (FDR: 3.85e-06); Synapse (GOCC:0045202) (FDR: 3.85e-06) *(Total significant: 3)*
- Process: Regulation of nervous system process (GO:0031644) (FDR: 1.70e-04); Modulation of chemical synaptic transmission (GO:0050804) (FDR: 4.00e-04); Regulation of postsynaptic neurotransmitter receptor activity (GO:0098962) (FDR: 8.90e-04); Chemical synaptic transmission (GO:0007268) (FDR: 0.005) *(Total significant: 4)*
- Component: Postsynaptic density (GO:0014069) (FDR: 2.26e-07); Synapse (GO:0045202) (FDR: 2.32e-05); Glutamatergic synapse (GO:0098978) (FDR: 1.80e-04); Anchoring junction (GO:0070161) (FDR: 0.007); Somatodendritic compartment (GO:0036477) (FDR: 0.012) *(Total significant: 5)*
- DISEASES: Autosomal dominant cerebellar ataxia (DOID:1441) (FDR: 0.050) *(Total significant: 1)*
- Keyword: Synapse (KW-0770) (FDR: 0.001); Spinocerebellar ataxia (KW-0950) (FDR: 0.001); Cell junction (KW-0965) (FDR: 0.001) *(Total significant: 3)*
- KEGG: Adrenergic signaling in cardiomyocytes (hsa04261) (FDR: 0.022); Hippo signaling pathway (hsa04390) (FDR: 0.022); Tight junction (hsa04530) (FDR: 0.022); Long-term potentiation (hsa04720) (FDR: 0.049); Amphetamine addiction (hsa05031) (FDR: 0.049) ... *(Total significant: 6. See string_terms.csv for full list.)*
- InterPro: SAPAP family (IPR005026) (FDR: 5.19e-05) *(Total significant: 1)*
- Pfam: Guanylate-kinase-associated protein (GKAP) protein (PF03359) (FDR: 1.67e-05) *(Total significant: 1)*
- PMID: (2013) CaMKII regulates diacylglycerol lipase-alpha and striatal endocannabinoid signaling. (PMID:23502535) (FDR: 1.48e-06); (2021) mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving. (PMID:33444640) (FDR: 2.54e-06); (2022) Deep Single-Cell-Type Proteome Profiling of Mouse Brain by Nonsurgical AAV-Mediated Proximity Labeling. (PMID:35315655) (FDR: 7.53e-06); (2021) Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimers disease. (PMID:34326412) (FDR: 7.53e-06); (2021) Synaptic Protein Phosphorylation Networks Are Associated With Electroacupuncture-Induced Circadian Control in the Suprachiasmatic Nucleus. (PMID:34976011) (FDR: 2.32e-05) ... *(Total significant: 67. See string_terms.csv for full list.)*
- RCTM: Neurexins and neuroligins (HSA-6794361) (FDR: 2.50e-07); Neuronal System (HSA-112316) (FDR: 6.21e-07); Unblocking of NMDA receptors, glutamate binding and activation (HSA-438066) (FDR: 0.037); Ras activation upon Ca2+ influx through NMDA receptor (HSA-442982) (FDR: 0.037); Negative regulation of NMDA receptor-mediated neuronal transmission (HSA-9617324) (FDR: 0.037) ... *(Total significant: 6. See string_terms.csv for full list.)*
- WikiPathways: Disruption of postsynaptic signaling by CNV (WP4875) (FDR: 2.68e-06); Fragile X syndrome (WP4549) (FDR: 0.015) *(Total significant: 2)*
- HPO: Alzheimers disease biomarker measurement (EFO:0006514) (FDR: 0.021) *(Total significant: 1)*
- NetworkNeighborAL: Neurexins and neuroligins (CL:22982) (FDR: 2.36e-08); Neurexins and neuroligins (CL:22984) (FDR: 8.92e-07); Vocalization behavior, and Homer family (CL:22986) (FDR: 0.032) *(Total significant: 3)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Positive Regulation of T-helper 2 Cell Differentiation (GO:0045630) (Adj. P: 0.030, Combined Score: 2946.37); Regulation of Mitochondrial Membrane Permeability Involved in Apoptotic Process (GO:1902108) (Adj. P: 0.030, Combined Score: 2946.37); Modulation of Chemical Synaptic Transmission (GO:0050804) (Adj. P: 2.88e-07, Combined Score: 2911.35); Positive Regulation of Interleukin-5 Production (GO:0032754) (Adj. P: 0.030, Combined Score: 2284.21); Regulation of Trans-Synaptic Signaling (GO:0099177) (Adj. P: 1.01e-04, Combined Score: 2232.29) ... *(Total significant: 75. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Adenylate Cyclase Inhibiting G Protein-Coupled Glutamate Receptor Activity (GO:0001640) (Adj. P: 0.037, Combined Score: 1549.44); Diacylglycerol-Dependent Serine/Threonine Kinase Activity (GO:0004697) (Adj. P: 0.037, Combined Score: 822.99); Glutamate Receptor Activity (GO:0008066) (Adj. P: 0.037, Combined Score: 583.76); Postsynaptic Neurotransmitter Receptor Activity (GO:0098960) (Adj. P: 0.037, Combined Score: 506.56); Lysophospholipase Activity (GO:0004622) (Adj. P: 0.037, Combined Score: 445.92) ... *(Total significant: 10. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: PAR Polarity Complex (GO:0120157) (Adj. P: 0.021, Combined Score: 2946.37); Neuronal Dense Core Vesicle (GO:0098992) (Adj. P: 0.021, Combined Score: 2946.37); G Protein-Coupled Receptor Dimeric Complex (GO:0038037) (Adj. P: 0.021, Combined Score: 2284.21); Neuron to Neuron Synapse (GO:0098984) (Adj. P: 0.025, Combined Score: 1326.33); Glutamatergic Synapse (GO:0098978) (Adj. P: 6.19e-04, Combined Score: 812.85) ... *(Total significant: 8. See enrichr_terms.csv for full list.)*
- Reactome_2022: Neurexins And Neuroligins R-HSA-6794361 (Adj. P: 1.04e-06, Combined Score: 3818.44); Protein-protein Interactions At Synapses R-HSA-6794362 (Adj. P: 3.68e-06, Combined Score: 2166.26); Neuronal System R-HSA-112316 (Adj. P: 1.04e-06, Combined Score: 1094.24); Opioid Signaling R-HSA-111885 (Adj. P: 0.025, Combined Score: 353.94) *(Total significant: 4)*
- Human_Phenotype_Ontology: Sensorimotor neuropathy (HP:0007141) (Adj. P: 3.21e-04, Combined Score: 4339.90); Dysdiadochokinesis (HP:0002075) (Adj. P: 3.58e-04, Combined Score: 2602.87); Dysmetria (HP:0001310) (Adj. P: 5.20e-05, Combined Score: 2362.47); Abnormality of saccadic eye movements (HP:0000570) (Adj. P: 7.61e-04, Combined Score: 1372.44); Action tremor (HP:0002345) (Adj. P: 0.016, Combined Score: 1326.33) ... *(Total significant: 22. See enrichr_terms.csv for full list.)*
- OMIM_Disease: spinocerebellar ataxia (Adj. P: 0.033, Combined Score: 216.36); ataxia (Adj. P: 0.033, Combined Score: 115.73) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 20 (k=21)

This cluster contains 5 genes.
Average Silhouette Score: -0.009.
Highest expression is observed in: Brain - Cerebellar Hemisphere, Brain - Cerebellum, Pituitary, Thyroid, Brain - Frontal Cortex (BA9).
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Lymphocyte Migration Into Lymphoid Organs (GO:0097021) (Adj. P: 0.025, Combined Score: 6499.56); S-adenosylmethionine Metabolic Process (GO:0046500) (Adj. P: 0.025, Combined Score: 3326.77); Positive Regulation of Oxidoreductase Activity (GO:0051353) (Adj. P: 0.025, Combined Score: 2946.37); Steroid Hormone Receptor Signaling Pathway (GO:0043401) (Adj. P: 0.025, Combined Score: 2638.91); Glial Cell-Derived Neurotrophic Factor Receptor Signaling Pathway (GO:0035860) (Adj. P: 0.025, Combined Score: 2638.91) ... *(Total significant: 20. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: UDP Phosphatase Activity (GO:0045134) (Adj. P: 0.016, Combined Score: 4436.86); GDP Phosphatase Activity (GO:0004382) (Adj. P: 0.016, Combined Score: 3808.55); Estrogen Response Element Binding (GO:0034056) (Adj. P: 0.016, Combined Score: 3326.77); Nucleoside Diphosphate Phosphatase Activity (GO:0017110) (Adj. P: 0.016, Combined Score: 2173.55); Nuclear Steroid Receptor Activity (GO:0003707) (Adj. P: 0.016, Combined Score: 1705.22) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- Reactome_2022: Vitamin B2 (Riboflavin) Metabolism R-HSA-196843 (Adj. P: 0.026, Combined Score: 5287.72); Phosphate Bond Hydrolysis By NTPDase Proteins R-HSA-8850843 (Adj. P: 0.026, Combined Score: 4436.86); Bicarbonate Transporters R-HSA-425381 (Adj. P: 0.026, Combined Score: 3326.77); SUMOylation Of Intracellular Receptors R-HSA-4090294 (Adj. P: 0.044, Combined Score: 878.83); Nucleotide Catabolism R-HSA-8956319 (Adj. P: 0.044, Combined Score: 696.01) ... *(Total significant: 7. See enrichr_terms.csv for full list.)*
- MSigDB_Hallmark_2020: Bile Acid Metabolism (Adj. P: 0.049, Combined Score: 160.62); UV Response Up (Adj. P: 0.049, Combined Score: 102.58); Estrogen Response Early (Adj. P: 0.049, Combined Score: 75.00); Estrogen Response Late (Adj. P: 0.049, Combined Score: 75.00) *(Total significant: 4)*
- Human_Phenotype_Ontology: Adrenal overactivity (HP:0002717) (Adj. P: 0.002, Combined Score: 5105.23); Pheochromocytoma (HP:0002666) (Adj. P: 0.016, Combined Score: 4436.86); Decreased circulating renin level (HP:0003351) (Adj. P: 0.016, Combined Score: 4436.86); Hyperactive renin-angiotensin system (HP:0000841) (Adj. P: 0.016, Combined Score: 4436.86); Increased circulating renin level (HP:0000848) (Adj. P: 0.016, Combined Score: 4436.86) ... *(Total significant: 80. See enrichr_terms.csv for full list.)*
- OMIM_Disease: thyroid carcinoma (Adj. P: 0.007, Combined Score: 1705.22); hypertension (Adj. P: 0.007, Combined Score: 878.83) *(Total significant: 2)*

Top Genes (by silhouette):

Cluster 21 (k=21)

This cluster contains 6 genes.
Average Silhouette Score: 0.121.
Highest expression is observed in: Brain - Cerebellum, Brain - Cerebellar Hemisphere, Brain - Nucleus accumbens (basal ganglia), Brain - Frontal Cortex (BA9), Brain - Cortex.
*(Showing top 5 tissues. Refer to full expression matrix for all values.)*

STRING network enrichment:
*(Thresholds: FDR < 0.05. Showing top 5 terms per category.)*
- COMPARTMENTS: Inhibitory synapse (GOCC:0060077) (FDR: 0.024); Spanning component of membrane (GOCC:0089717) (FDR: 0.024); GABA-ergic synapse (GOCC:0098982) (FDR: 0.024); Excitatory synapse (GOCC:0060076) (FDR: 0.028) *(Total significant: 4)*
- Process: Positive regulation of transport (GO:0051050) (FDR: 0.010); Terminal button organization (GO:0072553) (FDR: 0.010); Postsynaptic density protein 95 clustering (GO:0097119) (FDR: 0.010); Positive regulation of secretion by cell (GO:1903532) (FDR: 0.010); Positive regulation of hormone secretion (GO:0046887) (FDR: 0.013) ... *(Total significant: 26. See string_terms.csv for full list.)*
- Component: GABA-ergic synapse (GO:0098982) (FDR: 0.003); Integral component of postsynaptic membrane (GO:0099055) (FDR: 0.005); Spanning component of membrane (GO:0089717) (FDR: 0.005); Inhibitory synapse (GO:0060077) (FDR: 0.006); Dendritic shaft (GO:0043198) (FDR: 0.013) ... *(Total significant: 9. See string_terms.csv for full list.)*
- Function: Neurexin family protein binding (GO:0042043) (FDR: 0.046) *(Total significant: 1)*
- InterPro: Neuroligin (IPR000460) (FDR: 0.012); Carboxylesterase, type B (IPR002018) (FDR: 0.029); Carboxylesterase type B, conserved site (IPR019819) (FDR: 0.029) *(Total significant: 3)*
- Pfam: Alpha/beta hydrolase fold (PF07859) (FDR: 0.037) *(Total significant: 1)*
- WikiPathways: Disruption of postsynaptic signaling by CNV (WP4875) (FDR: 0.036) *(Total significant: 1)*

Enrichr annotation enrichment:
*(Thresholds: Adj. P < 0.05, Combined Score > 10. Showing top 5 terms per library.)*
- GO_Biological_Process_2025: Postsynaptic Density Protein 95 Clustering (GO:0097119) (Adj. P: 6.96e-05, Combined Score: 46990.97); Postsynaptic Membrane Assembly (GO:0097104) (Adj. P: 6.96e-05, Combined Score: 46990.97); Postsynapse Assembly (GO:0099068) (Adj. P: 6.96e-05, Combined Score: 26709.22); Positive Regulation of Synaptic Transmission, GABAergic (GO:0032230) (Adj. P: 6.96e-05, Combined Score: 21777.60); Postsynaptic Density Organization (GO:0097106) (Adj. P: 6.96e-05, Combined Score: 21777.60) ... *(Total significant: 164. See enrichr_terms.csv for full list.)*
- GO_Molecular_Function_2025: Neurexin Family Protein Binding (GO:0042043) (Adj. P: 6.07e-05, Combined Score: 15739.23); Non-Membrane Spanning Protein Tyrosine Phosphatase Activity (GO:0004726) (Adj. P: 0.013, Combined Score: 6499.56); Insulin Receptor Binding (GO:0005158) (Adj. P: 0.034, Combined Score: 1147.41); Phosphotyrosine Residue Binding (GO:0001784) (Adj. P: 0.040, Combined Score: 483.15); Signaling Receptor Complex Adaptor Activity (GO:0030159) (Adj. P: 0.040, Combined Score: 402.08) ... *(Total significant: 11. See enrichr_terms.csv for full list.)*
- GO_Cellular_Component_2025: Symmetric Synapse (GO:0032280) (Adj. P: 0.007, Combined Score: 6499.56); GABA-ergic Synapse (GO:0098982) (Adj. P: 3.78e-04, Combined Score: 5171.67); G Protein-Coupled Receptor Dimeric Complex (GO:0038037) (Adj. P: 0.007, Combined Score: 5053.71); Inhibitory Synapse (GO:0060077) (Adj. P: 0.007, Combined Score: 4108.59); Synaptic Membrane (GO:0097060) (Adj. P: 6.12e-04, Combined Score: 2482.01) ... *(Total significant: 13. See enrichr_terms.csv for full list.)*
- Reactome_2022: MET Activates PTPN11 R-HSA-8865999 (Adj. P: 0.026, Combined Score: 6499.56); STAT5 Activation R-HSA-9645135 (Adj. P: 0.026, Combined Score: 4108.59); Netrin Mediated Repulsion Signals R-HSA-418886 (Adj. P: 0.026, Combined Score: 3445.29); Activated NTRK2 Signals Thru FRS2 And FRS3 R-HSA-9028731 (Adj. P: 0.026, Combined Score: 2955.69); MAPK1 (ERK2) Activation R-HSA-112411 (Adj. P: 0.026, Combined Score: 2955.69) ... *(Total significant: 122. See enrichr_terms.csv for full list.)*
- Human_Phenotype_Ontology: Multiple enchondromatosis (HP:0005701) (Adj. P: 0.022, Combined Score: 3445.29); Abnormality of the left ventricular outflow tract (HP:0011103) (Adj. P: 0.022, Combined Score: 3445.29); Subaortic stenosis (HP:0001682) (Adj. P: 0.022, Combined Score: 3445.29); Unilateral renal agenesis (HP:0000122) (Adj. P: 0.022, Combined Score: 2955.69); Bundle branch block (HP:0011710) (Adj. P: 0.022, Combined Score: 2580.41) ... *(Total significant: 72. See enrichr_terms.csv for full list.)*
- OMIM_Disease: leukemia (Adj. P: 0.023, Combined Score: 194.75) *(Total significant: 1)*

Top Genes (by silhouette):